Complexes of nucleic acid and polymer, their process of preparat

Details Complexes of nucleic acid and polymer, their process of preparat Complexes of nucleic acid and polymer, their process of preparat

1996-10-31

1998-03-31

Elliott, George C.

Chemistry: molecular biology and microbiology

Treatment of micro-organisms or enzymes with electrical or...

Modification of viruses

435325, 514 44, 530300, 530345, 530350, 530395, 530402, 536 232, 536 235, 536 245, 536 237, C07K 100, C07K 1107, C12N 1500, C12N 1588

Patent

active

057337624

ABSTRACT:
A compound consisting essentially of polylysine conjugated to non-charged residues and recognition signals wherein the free amino functions of said polylysine are substituted with non-charged residues and said recognition signals, which non-charged residues consist of gluconalactone and which recognition signals are at least one member of the group consisting of galactoside, mannoside, fucoside, Lewis.sup.x, Lewis.sup.b, oligomannoside, oligolactosamine saccharides and peptide ANP and said conjugated polylysine contains at least 30% unsubstituted free amino functions and a method of transfecting cultured cells.

REFERENCES:
patent: 5595897 (1997-01-01), Midoux et al.
Crystal. "Transfer of Genes to Humans: Early Lessons and Obstacles to Success" Science 270: 404-410, Oct. 1995.
Gura. "Antisense has Growing Pains" Science 270: 575-677, Oct. 1995.
Stull et al. Antigene, Ribozyme, and Aptamer Nucleic Acid Drugs: Prospect and Progress Pharm. Rev. 12: 465-483, Apr. 1995.

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