Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1992-06-30
1993-10-05
Hollrah, Glennon H.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
544382, 546205, 546206, 546223, 546244, 546264, 546329, 546332, 514319, 514329, 514332, 514611, A01N 4340
Patent
active
052505502
ABSTRACT:
There are disclosed novel complexes of nitric oxide and polyamines which are useful in treating cardiovascular disorders, including hypertension. The disclosed compounds release nitric oxide (endothelium-derived relaxing factor) under physiological conditions in a sustained and controllable fashion, and possess long mechanisms of action.
REFERENCES:
Marmo et al. Biomed. Biochem. Acta. 43:509-15 (1984).
Palmer et al. Nature 327:524-6 (1987).
Robert F. Furchgott, Ann. Rev. Pharm. Toxicol., 1984, 24:175-97.
H. Kruszyna et al, Toxicology and Applied Pharmacol., 1987, 91:429-438.
Louis J. Ignarro, The FASEB Journal, vol. 3, Jan. 1989; pp. 31-36.
Louis J. Ignarro et al, The Journal of Pharmacology and Experimental Therapeutics, vol. 218, No. 3, 1981; pp. 739-749.
Raymond Longhi et al, Inorg. Chemistry, 1(3), 768-770 (1962).
Daniel O. Alonso Garrido et al, Am. Chem. Soc., 1984, vol. 49, pp. 2021-2023.
Raymond J. Bergeron, Acc. Chem. Res. 1986, vol. 19, pp. 105-113.
Raymond J. Bergeron et al, J. Org. Chem. 1984, vol. 49, pp. 2997-3001.
Raymond J. Bergeron et al, J. Org. Chem., 1988, vol. 53, pp. 3108-3111.
Tetrahedron Letters, vol. 29, No. 11, pp. 1279-1282, 1988. Carboni et al.
Henry E. Reich et al J. Amer. Chem. Soc., vol. 77, 5434-5436 (1955).
George Magnus et al, J. Amer. Chem. Soc., vol. 78, pp. 4127-4130 (1956).
R. S. Drago et al, J. Am. Chem. Soc., vol. 83, pp. 1819-1822 (1961).
Hrabie Joseph A.
Keefer Larry K.
Burn Brian M.
Hollrah Glennon H.
The Government of the United States of America as represented by
LandOfFree
Complexes of nitric oxide with polyamines does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Complexes of nitric oxide with polyamines, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Complexes of nitric oxide with polyamines will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1004161