Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1994-03-17
1996-01-09
O'Sullivan, Peter
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
514 2, 514 21, 514 56, 514565, 530300, 530311, 530316, 530350, 530855, 536 21, 562560, A61K 3808, A61K 3816, A61K 3817, A61K 3831
Patent
active
054829259
ABSTRACT:
Novel complexes of nitric oxide (NO) and amines are described where the amine is a known cardiovascular agent having at least one or more primary or secondary amino groups and whereby the resulting complex is capable under physiological conditions of releasing in vivo dual active ingredients, the NO and the known cardiovascular agent. The complexes are used for treating cardiovascular diseases and for the prophylactic or therapeutic treatment of restenosis.
REFERENCES:
patent: 4954526 (1990-09-01), Keefer
patent: 5039705 (1991-08-01), Keefer et al.
patent: 5155137 (1992-10-01), Keefer et al.
Ignarro et al., "Endothelium--derived nitric oxide: actions and properties," FASEB Journal, vol. 3, No. 1 Jan. 1989, pp. 31-36.
Toxicology and Applied Pharmacology, 91, 429-438 (1987), "Red Blood Cells Generate nitric Oxide from Directly Acting, Nitrogenous Vasodilators", by Harriet Kruszyna et al.
The Journal of Pharmacology and Experimental Therapeutics, vol. 218, No. 3, 1981, "Mechanism of Vascular Smooth Muscle Relaxation by Organic Nitrates, Nitrites, Nitroprusside and Nitric Oxide: Evidence for the Involvement of S-Nitrosothiols as Active Intermediates", by Ignarro et al., pp. 739-749.
J. Am. Chem. Soc., vol. 83, pp. 1819-1822 (1961), "The Reaction of Nitrogen(II) Oxide with Various Primary and Secondary Amines", by Russell S. Drago et al.
Nature, vol. 327, pp. 524-526, (1987), "Nitric Oxide Release Accounts for the Biological Activity of Endothelium-derived Relaxing Factor", by Palmer et al.
Arteriosclerosis, vol. 10, No. 6, (1990), pp. 966-990, "Regulation of Differentiated Properties and Proliferation of Arterial Smooth Muscle Cells", by Thyberg et al.
Journal of American College of Cardiology, vol. 17, No. 6, (1991), pp. 132B-136B, "Peptide Inhibition of Myointimal Proliferation by Angiopeptin, a Somatostatin Analogue", by Lundergan et al.
Transplantation Proceedings, vol. 21, No. 4, (1989), pp. 3686-3688, "Peptide Inhibition of Myointimal Proliferation Following Angioplasty in Rabbits", by Conte et al.
Platelets in Biology and Pathology, (1976), pp. 23-60, Chapter 2, "Adhesion and Aggregation: Morphological Demonstration and Quantitation In Vivo and In Vitro", by Baumgartner et al.
Annual Review of Pharmacology and Toxicology, vol. 24, (1984), pp. 175-197, "The Role of Endothelium in the Responses of Vascular Smooth Muscle to Drugs" by Furchgott.
Journal of the American College of Cardiology, vol. 15, No. 2, (1990), pp. 419-425, "Primary Peripheral Arterial Stenoses and Restenoses Excised by Transluminal Atherectomy: A Histopathologic Study", by Johnson et al.
The American Journal of Cardiology, vol. 60, pp. 20B-28B, "Role of Platelets and Thrombosis in Mechanisms of Acute Occlusion and Restenosis after Angioplasty", by Laurence Harker, (1987).
Biochemical Pharmacology, vol. 38, No. 7, (1989), pp. 1709-1715, "Biosynthesis of Nitric Oxide from L-Arginine: A Pathway for the Regulation of Cell Function and Communication", by Moncada et al.
Circulation Research, vol. 56, (1985), pp. 139-145, "Significance of Quiescent Smooth Muscle Migration in the Injured Rat Carotid Artery", by Clowes et al.
Circulation Research, vol. 46, (1980), pp. 625-634, "Inhibition of Rat Arterial Smooth Muscle Cell Proliferation by Heparin", by Guyton et al.
Circulation, vol. 79, No. 3, (1989), pp. 657-665), "Effects of Thrombin Inhibition on the Development of Acute Platelet-Thrombus Deposition During Angioplasty in Pigs", by Heras et al.
The Journal of Clinical Investigation, vol. 75, No. 5, (1985), pp. 1914-1918, "Evidence for a Functional Role of Endogenously Produced Somatomedinlike Peptides in the Regulation of DNA Synthesis in Cultured Human Fibroblasts and Porcine Smooth muscle Cells", by Clemmons et al.
Proceedings of the National Academy of Sciences, vol. 87, No. 13, (1990), pp. 5193-5197, "An L-Arginine/Nitric Oxide Pathway Present in Human Platelets Regulates Aggregation", by Radomski et al.
Nature, vol. 265, (1977), "Suppression by Heparin of Smooth Muscle Cell Proliferation in Injured Arteries", by Clowes et al., pp. 625-626.
Comedicus Incorporated
O'Sullivan Peter
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