Complexes of heavy metal ions and polyfunctional organic ligands

Details Complexes of heavy metal ions and polyfunctional organic ligands Complexes of heavy metal ions and polyfunctional organic ligands

1975-07-21

1977-10-25

Schenkman, Leonard

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Recombinant or stably-transformed bacterium encoding one or...

424289, 424290, 424291, 424292, 424295, 424296, 424287, A01N 900

Patent

active

040556557

ABSTRACT:
Antimicrobial agents are disclosed containing as the active ingredient a metal complex of a metal ion and a polyfunctional organic ligand. The antimicrobial metal complexes are characterized by a very unexpected aqueous proton induced dissociation property which causes the controlled release of toxic metal ion at a pH compatible with microorganism growth. This dissociation property is represented by a sigmoidally shaped curve, i.e., one curved in two different directions like the letter "S," on a cartesian coordinate plot of the negative logarithm (log) of metal ion concentration versus the negative logarithm (log) of hydrogen ion concentration (or otherwise known as a pM-pH diagram). Antimicrobial metal complexes are also disclosed which are extremely effective in the controlled release of metal ion from the complex in about the normal range of physiological pH, i.e., about 10.sup.- 4 to 10.sup.-9 moles of hydrogen ion per liter.

REFERENCES:
patent: 3076834 (1963-02-01), Norton
patent: 3300498 (1967-01-01), Gershon et al.
patent: 3799945 (1974-03-01), D'Amico
Bobtelsky et al. JACS. 67, pp. 1824-1831 (1945).
Chemical Abstracts 75:31794q (1971).
Chemical Abstracts 63:7876h (1965).
Chemical Abstracts 57:371d (1962).

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