Complexes of flavanolignans with phospholipids, preparation ther

Details Complexes of flavanolignans with phospholipids, preparation ther Complexes of flavanolignans with phospholipids, preparation ther

1986-07-07

1988-08-16

Chan, Nicky

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Phosphorus containing other than solely as part of an...

549400, 549362, 549289, A61K 31685, C07D31132, C07D31100, C07D31920

Patent

active

047645083

ABSTRACT:
The invention relates to novel compounds comprising lipophilic complexes of silybin, silidianin, and silicristin with phospholipids, and the preparation of these complexes by non-conventional methods. Absorption of the novel compounds in the gastrointestinal tract is appreciably greater, resulting in higher plasma levels than for the individual flavanolignans. The resulting improvement in the pharmacokinetic and pharmacological parameters is such that the substances can advantageously be used in the treatment of acute and chronic liver disease of toxic, metabolic or infective origin or of degenerative nature.

REFERENCES:
patent: 4358442 (1982-11-01), Wirte-Peitz et al.

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