Complexes of DNA and esters derived from daunorubicine, their pr

Details Complexes of DNA and esters derived from daunorubicine, their pr Complexes of DNA and esters derived from daunorubicine, their pr

1979-08-17

1981-07-07

Brown, Johnnie R.

Drug, bio-affecting and body treating compositions

Conjugate or complex of monoclonal or polyclonal antibody,...

Conjugated via claimed linking group, bond, chelating agent,...

536 17A, 536 22, 536 28, 536 29, A61K 3171, C07H 1524

Patent

active

042774667

ABSTRACT:
A complex of deoxyribonucleic acids (DNA) with an ester derived from daunorubicine of the formula ##STR1## in which R.sub.1 represents a radical of the formula ##STR2## in which each X represents oxygen or sulfur and each R.sub.3 represents alkyl, phenyl or both R.sub.3 form together with one another an alkylene group, R.sub.4 is hydrogen, alkyl or phenyl and R.sub.2 is hydrogen or trifluoracetyl.
Said complexes are usable for treating cancerous tumors.

REFERENCES:
patent: 3803124 (1974-04-01), Arcamone et al.
patent: 4031211 (1977-06-01), Patelli et al.
patent: 4127714 (1978-11-01), Umezawa et al.
Di Marco et al. "Chem. Abst", vol. 75, 1971 p. 71329y.

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