Complexes of AZO compounds and/or their salts and an antitumor a

Details Complexes of AZO compounds and/or their salts and an antitumor a Complexes of AZO compounds and/or their salts and an antitumor a

1986-05-20

1989-09-05

Higel, Floyd D.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Acyclic nitrogen double bonded to acyclic nitrogen, acyclic...

534643, 534787, 534827, 534829, 534832, 534646, 534728, 534653, 534716, 564210, 564428, 564443, 560163, C07C10700, C07C10704, C07C10706, C07C10708

Patent

active

048639109

ABSTRACT:
A complex of an azo compound of the formula ##STR1## wherein R and R' are selected from the group consisting of hydrogen, --COCR.sub.4.sup.3, --COCHR.sub.2.sup.4, --CO.sub.2 C.sub.2 H.sub.5, --CH.sub.2 CH.sub.2 R.sup.4, --(CH.sub.2 CH.sub.2 R.sup.4)2, --CH.sub.2 CH.sub.2 OH, --CONHCH.sub.2 CH.sub.2 R.sup.4 and --CH.sub.2 CH.sub.2 OCOHN.sub.2, R.sup.4 is selected from the group consisting of chlorine, ##STR2## --NHCO.sub.2 CH.sub.2 CH.sub.2 OH, --HNCO.sub.2 C.sub.2 H.sub.5, --NHOH, --NHCONHOH and --NHCH.sub.3 ; R.sup.1 and R.sup.2 are individually selected from the group consisting of ##STR3## --NHCH.sub.2 CH.sub.2 Cl, --NHCONHOH, --NHCO.sub.2 C.sub.2 H.sub.5, 6-mercapropurin, 5-fluoruracil and prenissolin, R.sup.3 is selected from the group consisting of hydrogen, --COCHR.sub.2.sup.4, --SO.sub.2 CH.sub.3, --COC.sub.2 H.sub.5, --CH.sub.2 CH.sub.2 R.sub.4 and --CONH.sub.2, R.sup.4 is the same as defined herein above, or their pharmaceutically acceptable metal salts, and an antitumor agent selected from the group consisting of nitrogen mustard, cyclophosphamid, thyothepa, 6-mercaptopurine, 5-fluoruracil, vinblastine, L-asparaginase and prednisolone and treatment of tumors and living tissue.

REFERENCES:
patent: 2243617 (1941-05-01), Bonhote et al.
patent: 3546202 (1970-12-01), Bydesinsky et al.
patent: 4145299 (1979-03-01), Ford et al.

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