Complexes of adenovirus with cationic molecules

Details Complexes of adenovirus with cationic molecules Complexes of adenovirus with cationic molecules

1996-11-22

1999-10-05

Ketter, James

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

424 932, 424 936, 435455, 435456, A61K 4800

Patent

active

059624299

ABSTRACT:
The present invention provides noncovalent complexes of cationic molecules and adenoviral vectors containing a transgene. The complexes of the invention exhibit increased efficiency of gene transfer to a target cell relative to adenoviral vectors alone. Methods of making and using the complexes are also provided. A method of delivering cystic fibrosis transmembrane conductance regulator to a CF patient utilizing a complex of cationic molecules and adenoviral vectors containing a transgene encoding a CFTR protein is provided.

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