Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Glycoprotein – e.g. – mucins – proteoglycans – etc.
Patent
1995-05-16
1998-06-16
Walsh, Stephen
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Glycoprotein, e.g., mucins, proteoglycans, etc.
530502, 435 691, C07K 1400, C07K 14045, C07K 1450
Patent
active
057672504
ABSTRACT:
Complexes between truncated human cytomegalovirus glycoprotein H (CMV gH) polypeptides and escort proteins are disclosed. The escort proteins include soluble fibroblast growth factor receptor polypeptide and a UL115 polypeptide. The escorts shuttle the CMV gH polypeptides to the cell surface. In this way, egress of the polypeptides out of the cell is facilitated, resulting in increased yields and easier purification of the truncated CMV gH.
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Blackburn Robert P.
Chiron Corporation
McClung Barbara G.
Robins Roberta L.
Teng Sally P.
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