Complexes and compositions for magnetic resonance imaging and us

Details Complexes and compositions for magnetic resonance imaging and us Complexes and compositions for magnetic resonance imaging and us

1990-11-21

1992-08-25

Raymond, Richard L.

Drug, bio-affecting and body treating compositions

In vivo diagnosis or in vivo testing

Magnetic imaging agent

436173, 436806, 1286534, 514492, 514502, 514836, 534 13, 534 16, 556 45, 556 57, 556110, 556138, G01N 2400, G01N 3100, A61K 3128, C07F 500

Patent

active

051417405

ABSTRACT:
Novel magnetic resonance imaging agents comprise complexes of paramagnetic ions with hydrazide derivatives of polyaminocarboxylic acid chelating agents. These novel imaging agents are characterized by excellent NMR image-contrasting properties and by high solubilities in physiological solutions. A novel method of performing an NMR diagnostic procedure involves administering to a warm-blooded animal an effective amount of a complex as described above and then exposing the warm-blooded animal to an NMR imaging procedure, thereby imaging at least a portion of the body of the warm-blooded animal.

REFERENCES:
patent: 4647447 (1987-03-01), Gries et al.
patent: 4687658 (1987-08-01), Quay
patent: 4687659 (1987-08-01), Quay
patent: 4826673 (1989-05-01), Dean et al.
Turowski, P. N. et al. Inorganic Chemistry 27(3):474-481 (1988).

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