Complexes and compositions for magnetic resonance imaging

Details Complexes and compositions for magnetic resonance imaging Complexes and compositions for magnetic resonance imaging

1992-06-03

1993-06-08

Robinson, Allen J.

Drug, bio-affecting and body treating compositions

In vivo diagnosis or in vivo testing

Magnetic imaging agent

436173, 534 13, 534 16, 1286534, 540465, 540467, 540541, 540544, 544 64, 544 72, 548106, 548240, 548951, 514184, 514836, G01N 2408, A61K 31555, C07D22500, C07D22300

Patent

active

052177068

ABSTRACT:
Novel magnetic resonance imaging agents comprise complexes of paramagnetic ions with hydrazide derivatives of polyaminocarboxylic acid chelating agents. These novel imaging agents are characterized by excellent NMR image-contrasting properties and by high solubilities in physiological solutions.
A novel method of performing an NMR diagnostic procedure involves administering to a warm-blooded animal an effective amount of a complex as described above and then exposing the warm-blooded animal to an NMR imaging procedure, thereby imaging at least a portion of the body of the warm-blooded animal.

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Turowski, P. N. et al., Inorganic Chemistry 27(3):474-481 (1988).

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