Complexation of anthracycline and anthraquinone antibiotics by t

Details Complexation of anthracycline and anthraquinone antibiotics by t Complexation of anthracycline and anthraquinone antibiotics by t

1982-10-20

1985-08-13

Wiseman, Thomas G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

260112R, 260112B, 2601125R, 424 18, 435 78, 514251, C12N 1102, A01N 3100, C07C10352, C07G 700, A23J 100, C12P 1956

Patent

active

045349711

ABSTRACT:
A method for the preparation of light-stable water-soluble complexes of antitumor antibiotics and binding protein and the resulting products. The antibiotics are of the anthracycline and anthraquinone classes, as defined. The binding protein is purified apo riboflavin binding protein from eggs. The complexes are prepared by admixing solutions of the antibiotic and protein in substantially equimolar proportions. The complexes are useful for preparing stable aqueous solutions of the antibiotics for oral delivery and for redox titrations of anthracyclines.

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