Complex suitable for carrying out a method of purifying pre-S he

Details Complex suitable for carrying out a method of purifying pre-S he Complex suitable for carrying out a method of purifying pre-S he

1991-11-08

1993-12-28

Nucker, Christine M.

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

Separation or purification

530412, 530402, 530403, 530362, 530363, 530364, 530350, 424 89, 435239, C07K 312, C07K 1700, A61K 3912, C12N 702

Patent

active

052740811

ABSTRACT:
There is disclosed a complex comprised of an insoluble polymer carrier to which monomeric human albumin is covalently bound and of a pre-S hepatitis B surface antigen bound in an elutable form to the monomeric human albumin by its pre-S(2)- and/or pre-S(1)-region. This complex may be used for therapeutic and diagnostic purposes and enables the rapid and efficient purification of pre-S-HBsAg by affinity chromatography.

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