Complex salts of hematoporphyrin and of its derivatives, their s

Details Complex salts of hematoporphyrin and of its derivatives, their s Complex salts of hematoporphyrin and of its derivatives, their s

1992-10-29

1995-09-19

Shah, Mukund J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514397, 540145, A61K 3140, C07D48722

Patent

active

054515998

ABSTRACT:
New complex salts of hematoporphyrin and of its derivatives have the general Formula 1 (FIG. 1). The method of preparation of new complex salts of Formula 1 consists of reacting, with a basic amino acid, hematoporphyrin derivatives of general Formula 4 (FIG. 4). The new complex salts are used as a therapeutic agent for detection and treatment of neoplasms.

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Rimington et al., Chem. Abstracts, vol. 70, 1969; 66242g.
Krieg, M. et al. "Self-Sensitized Photooxidation . . . " J. Am. Chem. Soc., American Chemical Society 1984, 106, pp. 2477-2479.
Richard L. Lipton, et al, The Use of a Derivative of Hematoporphyrin in Tumor Detection, vol. 26, No. 1, Jan. 1961, Journal of the National Cancer Institute.

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