Complex of transferrin with ruthenium for medical applications

Details Complex of transferrin with ruthenium for medical applications Complex of transferrin with ruthenium for medical applications

1980-11-03

1984-05-15

Nucker, Christine M.

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

424 9, 260112B, A61K 4900, A61K 4300

Patent

active

044487622

ABSTRACT:
A novel Ruthenium-transferrin complex, prepared by reacting iron-free human transferrin dissolved in a sodium acetate solution at pH 7 with ruthenium by heating at about 40.degree. C. for about 2 hours, and purifying said complex by means of gel chromotography with pH 7 sodium acetate as eluent. The mono- or di-metal complex produced can be used in nuclear medicine in the diagnosis and/or treatment of tumors and abscesses. Comparative results with Ga-67-citrate, which is the most widely used tumor-localizing agent in nuclear medicine, indicate increased sensitivity of detection and greater tumor uptake with the Ru-transferrin complex.

REFERENCES:
patent: 3939258 (1976-02-01), Niemann
patent: 4057617 (1977-08-01), Abramovici et al.
patent: 4162142 (1979-07-01), Ehrenkaufer et al.
Subramanian et al., J. Nucl. Med., vol. 11, p. 365, (1970).
Radio Pharmaceuticals II: Proc. 2nd Int. Symposium on Radio Pharmaceuticals, (Mar. 1979), pp. 265-274.
Anghileri, Strahlentherapic, vol. 149, pp. 173-175, (1975).
Tanabe, Radio Isotopes, vol. 25, pp. 44-49, (1976).
Tanabe, Acta Medica Okayama, vol. 29, pp. 431-436, (1975).
Srivastava et al., Paper #BNL 27794, DOE, Mar. 1980.
Srivastava et al., Paper #BNL 27285, DOE, Jun. 1980.
Som et al., Paper #BNL 27969, DOE, Oct. 1980.
Oster et al., Paper #BNL 27737, DOE, Sep. 1980.

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