Drug – bio-affecting and body treating compositions – Inorganic active ingredient containing – Aluminum – calcium or magnesium element – or compound containing
Patent
1986-10-02
1990-04-03
Rollins, John W.
Drug, bio-affecting and body treating compositions
Inorganic active ingredient containing
Aluminum, calcium or magnesium element, or compound containing
4241951, 549399, 514456, A61K 3135, A61K 3308
Patent
active
049139096
ABSTRACT:
Extract of tea leaves or (-)-epigallocatechin gallate as the principal ingredient of the extract forms a complex with active aluminum hydroxide. The animal test using rats has established that these complexes have therapeutic effect for gastric ulcers, e.g. pylorus-ligated ulcer and indomethacin-induced ulcer, when orally administered. Tests were also undertaken for the effect on the secretion of gastric juice and acute toxicity of these complexes using rats and mice as the test animals.
REFERENCES:
patent: 2472476 (1949-06-01), Hardt
patent: 3975202 (1976-08-01), Emblem et al.
patent: 4003999 (1977-01-01), Lybrand et al.
patent: 4005191 (1977-01-01), Clark
patent: 4248789 (1981-02-01), Okada
patent: 4613672 (1986-09-01), Hara
patent: 4673530 (1987-06-01), Hara
"Anti-inflammatory Activity of (-)-Epicatechin, A Bioflavonoid Isolated from Anacardium occidentale Linn" by T. Swarenalakshmi et al, Indian J. Pharm. Sci. 1981, 43, pp. 205-208.
Journal of Pharmaceutical Sciences, vol. 65, No. 8 (Aug. 1976, pp. 1188-1191).
Horita et al. Chem Abs, 89, 12190n (1978).
Asai Hajime
Hara Yukihiko
Kitamikado Tadashi
Nakamura Kozo
Okushio Kazuo
Catchpole W.
Mitsui Norin Co., Ltd.
Rollins John W.
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