Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Reexamination Certificate
2006-12-12
2006-12-12
Salimi, Ali R. (Department: 1648)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
C435S005000
Reexamination Certificate
active
07148013
ABSTRACT:
Disclosed is a complex of the 11 kDa Ca2+binding protein of 11 and Hepatitis B virus polymerase (HBVPol) which moves to Promyelocytic Leukemia Nuclear Body (PMLNB). Furthermore, the present invention discloses a method for controlling movement of the HBVPol/p11 complex into the nucleus of HepG2 cell with adjusting of intracellular Ca2+ion concentration by administrating an agent for controlling calcium ion concentration in HepG2 cells.
REFERENCES:
patent: 2002/0045191 (2002-04-01), Schneider et al.
Bouchard, M.J. “Activation of Inhibition Cellular Calcium and Tyrosine Kinase Signaling Pathways Identify Targets of the HBx Protein Involved in Hepatitis B Virus Replication” J. Virol. (Jul. 2003) 77, 14, 7713-7719.
Science vol. 294, Dec. 14, 2001, pp. 2376-2378 “Calcium Signaling by HBx Protein in Hepatitis B Virus DNA Replication” by Michael J. Bouchard, Li-Hua Wang and Robert J. Schneider.
The EMBO Journal vol. 16 No. 1 pp. 59-68, 1997 “Hepadnavirus assembly and reverse transcription require a multi-component chaperone complex which is incorporated into nucleocapsids” by Jianming Hu, David O. Toft and Christoph Seeger.
Choi Juhyun
Han Ye Sun
Lim Dae-sik
Jones Day
Korea Institute of Science and Technology
Salimi Ali R.
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