Complex formation between dsDNA and oligomer of cyclic heterocyc

Details Complex formation between dsDNA and oligomer of cyclic heterocyc Complex formation between dsDNA and oligomer of cyclic heterocyc

1997-05-08

1999-12-07

Houtteman, Scott W.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

536 243, 536 245, C12Q 168

Patent

active

059981407

ABSTRACT:
Methods and compositions are provided for forming complexes intracellularly between dsDNA and oligomers of heterocycles, aliphatic amino acids, particularly omega-amino acids, and a polar end group. By appropriate choice of target sequences and composition of the oligomers, complexes are obtained with low dissociation constants. The formation of complexes can be used for modifying the phenotype of cells, either prokaryotic or eukaryotic, for research and therapy.

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