Complex containing coagulation factor IX

Details Complex containing coagulation factor IX Complex containing coagulation factor IX

1993-11-03

1995-04-25

Nutter, Nathan M.

Synthetic resins or natural rubbers -- part of the class 520 ser

Synthetic resins

Mixing of two or more solid polymers; mixing of solid...

530381, C08G 6348, C08G 6391, A61K 3514

Patent

active

054099900

ABSTRACT:
Factor IX is selectively adsorbed by means of hydrophobic chromatography from an aqueous mixture containing at least one plasma zymogen or a vitamin-K dependent protein in addition to factor IX. By this method, the efficient enrichment of factor IX for the production of pharmaceutical preparations has become possible.

REFERENCES:
patent: 4820805 (1989-04-01), Neurath et al.
patent: 5061789 (1991-10-01), Moller et al.
Einarsson et al., "Removal of Hepatitis B virus From A Concentrate Of Coagulation Factors II, VII, IX And X By Hydrophobic Interaction Chromatography", J. Vir. Met., 3:213-228 (1981).
Miletich et al., "The Synthesis of Sulfated Dextran Beads for Isolation of Human Plasma Coagulation Factors II, IX, and X", Anal. Biochem., 105:304-310 (1980).
H. G. J. Brummelhuis, "Preparation of the Prothrombin Complex", Methods of Plasma Protein Fractionation, ed. JM Curling, pp. 117-128, Acad. Press (1980).
Vukovich et al., "Separation of Human Blood Clotting Factors from Fibrinogen and other Plasma Proteins by Chromatography on Butyl-Sepharose", Folia Haematol, 107:1, 148-151 (1979).
Scopes, "Separation by Adsorption", Protein Purification Principles and Practice, 176-179 (1987).
A copy of the European search Report.

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