Complex compounds of platinum

Details Complex compounds of platinum Complex compounds of platinum

1985-07-10

1986-01-28

Sneed, Helen M. S.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heavy metal containing

548301, 514492, C07F 1500

Patent

active

045672857

ABSTRACT:
Disclosed herein are novel complex compounds of platinum showing an antitumor activity, represented by the formula(I): ##STR1## wherein one of R.sup.1 and R.sup.2 represents a group selected from the group consisting of (1) glucuronato groups whose hydroxyl groups may be acylated, (2) gluconato groups whose hydroxyl groups may be acylated, (3) pyruvato group and (4) nitrato group, and the other of R.sup.1 and R.sup.2 represents a group selected from the group consisting of (i) glucuronato groups whose hydroxyl groups may be acylated, (ii) gluconato groups whose hydroxyl groups may be acylated, (iii) pyruvato group and (iv) halogen atoms, or R.sup.1 and R.sup.2 represent together the group represented by the formula(II): ##STR2##

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Gale et al., "Perliminary Studies of 4-Carboxyphthalato(1,2-Diaminocyclohexane) Platinum(II) . . . ", J. Clin. Hematol. Oncol., 9 (No. 3), 217 (1979).
Speer et al., "Preclinical Evaluation of Bis(Pyruvato)1,2-Diaminocyclohexane Platinum(II) as a Potential Antitumor Agent," J. Clin. Hematol. Oncol., 13 (No. 4), 89 (1983).
Speer et al., "Antitumor Activity of Platinum Complexes of 1,2-Diaminocyclohexane Isomers," J. Clin. Hematol. Oncol., 8 (No. 2), 44 (1978).

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