Chemistry: analytical and immunological testing – Involving an insoluble carrier for immobilizing immunochemicals
Reexamination Certificate
2005-08-30
2005-08-30
Ponnaluri, Padmashri (Department: 1639)
Chemistry: analytical and immunological testing
Involving an insoluble carrier for immobilizing immunochemicals
C436S501000, C436S528000, C436S529000, C436S531000, C436S534000, C435S006120, C435S007100, C435S091500, C435S091500, C435S091500
Reexamination Certificate
active
06936477
ABSTRACT:
Encoded combinatorial chemistry is provided, where sequential synthetic schemes are recorded using organic molecules, which define choice of reactant, and stage, as the same or different bit of information. Various products can be produced in the multi-stage synthesis, such as oligomers and synthetic non-repetitive organic molecules. Conveniently, nested families of compounds can be employed as identifiers, where number and/or position of a substituent define the choice. Alternatively, detectable functionalities may be employed, such as radioisotopes, fluorescers, halogens, and the like, where presence and ratios of two different groups can be used to define stage or choice. Particularly, pluralities of identifiers may be used to provide a binary or higher code, so as to define a plurality of choices with only a few detachable tags. The particles may be screened for a characteristic of interest, particularly binding affinity, where the products may be detachable from the particle or retained on the particle. The reaction history of the particles which are positive for the characteristic can be determined by the release of the tags and analysis to define the reaction history of the particle.
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Dillard Lawrence W.
Ohlmeyer Michael H. J.
Reader John C.
Still W. Clark
Wigler Michael H.
Cold Spring Harbor Laboratory
Cooper & Dunham LLP
Ponnaluri Padmashri
The Trustees of Columbia University in the City of New York
White, Esq. John P.
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