Surgery – Diagnostic testing – Detecting nuclear – electromagnetic – or ultrasonic radiation
Reexamination Certificate
2007-03-09
2011-12-13
Casler, Brian (Department: 3737)
Surgery
Diagnostic testing
Detecting nuclear, electromagnetic, or ultrasonic radiation
C600S407000, C600S410000, C324S306000, C324S307000, C324S309000
Reexamination Certificate
active
08078257
ABSTRACT:
Systems and methods for blood flow and perfusion measurement using complex amplitude modulation of MRI pulses are presented. In exemplary embodiments of the disclosed subject matter, inflowing arterial spins can be modulated using a complex modulation function having certain mathematical properties in the frequency domain, such as, for example, a pseudo-random sequence. In exemplary embodiments of the disclosed subject matter the mathematical properties of such complex modulation functions can be used to measure individual transit times by deconvolving them from a series of acquired images. In exemplary embodiments of the disclosed subject matter images can be acquired at the same rapid rate as arterial modulation, and transit time distribution in the imaged tissue can be determined as part of a single integrated acquisition.
REFERENCES:
patent: 3786341 (1974-01-01), Anderson et al.
patent: 5865746 (1999-02-01), Murugesan et al.
patent: 6549007 (2003-04-01), Hills et al.
patent: 2004/0133927 (2004-07-01), Sternberg et al.
Calamante, F. et al., Measuring Cerebral Blood Flow Using Magnetic Resonance Imaging Techniques, Journal of Cerebral Blood Flow and Metablolism, (1999) 19, 701-735.
Barbier, E. et al., Methodology of Brain Perfusion Imaging, Journal of Magnetic Resonance Imaging, (2001) 13, 496-520.
Petersen, E. et al., Model-Free Arterial Spin Labeling Quantification Approach for Perfusion MRI, Magnetic Resonance in Medicine, (2006) 55, 219-232.
Golay, X. et al., Perfusion Imaging Using Arterial Spin Labeling, Topics in Magnetic Resonace Imaging, (2004) 15, 10-27.
Barbier, E. et al., Perfusion Analysis Using Dynamic Arterial Spin Labeling (DASL), Magnetic Resonance in Medicine 41:299-308 (1999).
Barbier, E. et al., Methodology of Brain Perfusion Imaging, Journal of Magnetic Resonance Imaging 13; 496-520 (2001).
Ogawa, S., Lee, T. M., Kay, A R. & Tank, D. W. Brain magnetic resonance imaging with contrast dependent on blood oxygenation. Proc Natl Acad Sci U S A 87, 9868-72 (1990).
Kety, S. S. & Schmidt, C. F. The determination of cerebral blood flow in man by use of nitrous oxide in low concentrations. Am J Physiol. 143, 53-66 (1945).
Ito, H., Kanno, I. & Fukuda, H. Human cerebral circulation: positron emission tomography studies. Ann Nucl Med 19, 65-74 (2005).
Williams, D. S., Detre, J. A. Leigh, J. S. & Koretsky, A. P. Magnetic resonance imaging of perfusion using spin inversion of arterial water. Proc Natl Acad Sci U S A 89, 212-6 (1992).
Kwong, K. K., Wanke, I., Donahue, K. M., Davis, T. L. & Rosen, B. R. EPI imaging of global increase of brain MR signal with breath-hold preceded by breathing O2. Magn Reson Med 33, 448-52 (1995).
Edelman, R. R. et al. Qualitative mapping of cerebral blood flow and functional localization with echo-planar MR imaging and signal targeting with alternating radio frequency. Radiology 192, 513-20 (1994).
Detre, J. A. et al. Tissue specific perfusion imaging using arterial spin labeling. NMR Biomed 7, 75-82 (1994).
Alsop, D. C. & Detre, J. A. Reduced transit-time sensitivity in noninvasive magnetic resonance imaging of human cerebral blood flow. J Cereb Blood Flow Metab 16, 1236-49 (1996).
Detre, J. A. & Wang, J. Technical aspects and utility of fMRI using BOLD and ASL. Clin Neurophysiol 113, 621-34 (2002).
Buxton, R. B. Quantifying CBF with arterial spin labeling. J Magn Reson Imaging 22, 723-6 (2005).
Baker & Botts LLP
Casler Brian
Siripurapu Rajeev
The Trustees of Columbia University in the City of New York
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