Complement stabilization

Details Complement stabilization Complement stabilization

1986-12-31

1990-09-11

Wallen, Thomas

Chemistry: analytical and immunological testing

Composition for standardization, calibration, simulation,...

Preservative, buffer, anticoagulant or diluent

436 16, 2524081, G01N 3354

Patent

active

049562991

ABSTRACT:
The present invention relates to a novel method for stabilizing aqueous solutions of serum complement for extended periods of time and the resultant stabilized complement solutions. More particularly, morphilino buffering compounds and tris-hydroxymethyl buffering compounds have been used to make aqueous buffers with a pH between about 6.5 and 8.5 and a concentration of greater than 0.01M. These buffers have been found to extend the normal life of complement solutions to unexpectedly longer periods.

REFERENCES:
patent: 3629142 (1971-12-01), Marbach
patent: 3682835 (1972-08-01), Louderback
patent: 4350659 (1982-09-01), Riceberg
patent: 4379847 (1983-04-01), Fruitstone et al.
patent: 4404285 (1983-09-01), Hou
patent: 4483921 (1984-11-01), Cole

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