Competitive homogeneous assay

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid

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436537, 436546, 935 78, C12Q 168

Patent

active

059288620

ABSTRACT:
Methods and compositions for performing assays for target polynucleotide strands include contacting a sample with a reagent which includes a first and a second polynucleotide probe. The first and second probes are capable of assuming a first position wherein the probes are bound to each other and a second position wherein the probes are bound to a target. The probes include label moieties capable of interacting to produce a signal indicative of the probes being in one of the two positions.

REFERENCES:
patent: 4562159 (1985-12-01), Shafritz
patent: 4568649 (1986-02-01), Bertoglio-Matte

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