Competitive binding assays having improved linearity

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

435 76, 435 793, 435962, 436536, 436537, G01N 33536, G01N 33542

Patent

active

059196424

ABSTRACT:
Simplified calibration and improved dose-response linearity of the standard curve of competitive assays are obtained by adding a predetermined amount of unlabeled competitive binding compound (usually just the analyte itself) to a first reagent containing anti-analyte antibodies before the reagent is reacted with a sample containing an unknown amount of analyte.

REFERENCES:
patent: 4378428 (1983-03-01), Farina et al.
patent: 4600690 (1986-07-01), Karmen et al.
patent: 4708429 (1987-11-01), Henderson
patent: 4785080 (1988-11-01), Farina et al.
patent: 4830959 (1989-05-01), McNeil et al.
patent: 4912041 (1990-03-01), Batchelor et al.
patent: 4950612 (1990-08-01), Khanna et al.
patent: 4956274 (1990-09-01), Khanna et al.
patent: 4963245 (1990-10-01), Weetall
patent: 5032503 (1991-07-01), Khanna et al.
patent: 5037735 (1991-08-01), Khanna et al.
patent: 5106950 (1992-04-01), Farina et al.
patent: 5120653 (1992-06-01), Henderson
patent: 5124253 (1992-06-01), Foulds et al.
patent: 5202233 (1993-04-01), Herrmann et al.
patent: 5212081 (1993-05-01), Coty et al.
patent: 5229282 (1993-07-01), Yoshioka et al.
patent: 5427912 (1995-06-01), Brown et al.
patent: 5444161 (1995-08-01), Manning et al.
patent: 5470713 (1995-11-01), El Shami et al.
Shaw et al. "Linearization of Data for Saturation-type Competitive Protein Binding Assay and Radioimmunoassay" Clinica. Chimica, ACTA (1977) 76(1):15-24.
E. T. Maggio, Enzyme-Immunoassay, CRC Press, Inc., 1980, pp. 106-107.
NR Rose et al (eds) "Manual of Clinical Laboratory Immunology" 3d ed, (1986), American Society for Microbioloby (Washington D.C.), pp. 89-98.
Declaration by William A. Coty.
Product insert and related information--Gentamicin CEDIA.RTM. assay.
Product insert and related information--Theophylline CEDIA.RTM. assay.
Product insert and related information--Tobramycin CEDIA.RTM. assay.
Product insert and related information--N-acetylprocainamide CEDIA.RTM. assay.
Gil et al., "Competitive heterogeneous enzyme immunoassay for theophyline by flow-injection analysis with electrochemical detection of .rho.-aminophenol" Clin. Chem. (1990) 36(4):662-665.
Jenkins et al., "Extending the detection limit of solid-phase electrochemical enzyme immunoassay to the attomole level" Anal. Biochem. (1988) 168:292-299.
Jenkins et al., "The use of ion pairing reagents to reduce non-specific adsorption in a solid phase electrochemical enzyme immunoassay" Contributed Article (1990) 13(2):99-104.
Thompson et al., "Comparison of methods for following alkaline phosphatase catalysis: spectrophotometric versus amperometric detection" Anal. Biochem. (1991) 192:90-95.
Wright et al., "Sequestration electrochemistry: the interaction of chlorpromazine and human orosomucoid" Anal. Biochem. (1988) 171:290-293.
Xu et al., "Heterogeneous enzyme immunoassay of alpha-fetoprotein in material serum by flow-injection amperiometric detection of 4-aminophenol" Clin. Chem. (1990) 36(11):1941-1944.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Competitive binding assays having improved linearity does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Competitive binding assays having improved linearity, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Competitive binding assays having improved linearity will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-898346

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.