Comparative fluorescence hybridization to nucleic acid arrays

Details Comparative fluorescence hybridization to nucleic acid arrays Comparative fluorescence hybridization to nucleic acid arrays

1994-12-09

1998-11-03

Jones, W. Gary

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

435 912, 536 243, 536 2433, 536 266, 382128, 382129, C12W 168, C12P 1934, C07H 2104

Patent

active

058306455

ABSTRACT:
The present invention provides methods of determining relative copy number of target nucleic acids and precise mapping of chromosomal abnormalities associated with disease. The methods of the invention use target nucleic acids immobilized on a solid surface, to which a sample comprising two sets of differentially labeled nucleic acids are hybridized. The hybridization of the labeled nucleic acids to the solid surface is then detected using standard techniques.

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