Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Patent
1998-04-03
1999-12-28
Ketter, James
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
424493, 424 9321, 514 44, C12N 1511
Patent
active
060083360
ABSTRACT:
Nucleic acids are compacted, substantially without aggregation, to facilitate their uptake by target cells of an organism to which the compacted material is administered. The nucleic acids may achieve a clinical effect as a result of gene expression, hybridization to endogenous nucleic acids whose expression is undesired, or site-specific integration so that a target gene is replaced, modified or deleted. The targeting may be enhanced by means of a target cell-binding moiety. The nucleic acid is preferably compacted to a condensed state.
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Ferkol Thomas W.
Hanson Richard W.
Perales Jose C.
Case Western Reserve University
Ketter James
Ohio University
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