Chemistry: molecular biology and microbiology – Vector – per se
Patent
1998-06-19
2000-10-17
Salimi, Ali
Chemistry: molecular biology and microbiology
Vector, per se
4352351, 435325, 536 2372, C12N 1500, C12N 700, C07H 2104
Patent
active
061330256
ABSTRACT:
Disclosed herein are nucleic acid sequences which support episomal replication in a mammalian cell. These nucleic acid sequences, which have a length of less than 3 kb, include (a) an OriP sequence and (b) an EBNA1 sequence operably linked to a promoter.
REFERENCES:
Belt et al., "Construction and properties of an Epstein-Barr-virus-derived cDNA expression vector for human cells," Gene 84:407-417, 1989.
Chittenden et al., "Functional limits of oriP, the Epstein-Barr virus plasmid origin of replication," Journal of Virology 63:3016-3025, 1989.
Inoue et al., "The domain of Epstein-Barr virus nuclear antigen 1 essential for binding to oriP region has a sequence fitted for the hypothetical basic-helix-loop-helix structure," Virology 182:84-93, 1991.
Jones et al., "Interaction of the lymphocyte-derived Epstein-Barr virus nuclear antigen EBNA-1 with its DNA-binding sites," Journal of Virology 63:101-110, 1989.
Kirchmaier and Sugden, "Dominant-negative inhibitors of EBNA-1 of Epstein-Barr virus," Journal of Virology 71:1766-1775, 1997.
Yates et al., "A cis-acting element from the Epstein-Barr viral genome that permits stable replication of recombinant plasmids in latently infected cells," Proc. Natl. Acad. Sci. USA 81:3806-3810, 1984.
Yates et al., "Stable replication of plasmids derived from Epstein-Barr virus in various mammalian cells," Nature 313:812-815, 1985.
Robert et al. J.of Virology, 1984, vol. 50, No. 3, pp. 822-831, Jun. 1984.
Elbing Karen L.
Salimi Ali
The General Hospital Corporation
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