Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Reexamination Certificate
2007-04-24
2007-04-24
Kemmerer, Elizabeth (Department: 1646)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
C435S007100, C435S252300, C435S254200, C435S320100, C435S325000, C435S348000, C435S349000, C435S358000, C435S363000, C435S365000, C435S367000, C435S419000, C435S455000, C530S350000, C536S023500
Reexamination Certificate
active
10333191
ABSTRACT:
The present invention is directed to a specific mutation in SCN5A which causes drug-induced torsade de pointes or ventricular fibrillation. Persons with the mutation are predisposed to developing drug-induced torsade de pointes or ventricular fibrillation when administered certain drugs. This predisposition can be diagnosed in accordance with the present invention by analyzing the DNA sequence of the SCN5A of an individual. By screening patients for the mutation, drug-induced torsade de pointes or ventricular fibrillation can be avoided. Furthermore, drugs can be tested to determine whether they will cause torsade de pointes or ventricular fibrillation.
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Keating Mark T.
Splawski Igor
Howard Zachary C.
Kemmerer Elizabeth
Rothwell Figg Ernst & Manbeck P.C.
University of Utah Research Foundation
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