Common lymphatic endothelial and vascular endothelial...

Details Common lymphatic endothelial and vascular endothelial... Common lymphatic endothelial and vascular endothelial...

2008-04-08

2008-04-08

Haddad, Maher M. (Department: 1644)

Drug, bio-affecting and body treating compositions

Immunoglobulin, antiserum, antibody, or antibody fragment,...

C424S143100, C424S153100

Reexamination Certificate

active

10497991

ABSTRACT:
A novel protein Common Lymphatic Endothelial and Vascular Endothelial Receptor-1 (CLEVER-1) is described. CLEVER-1 mediates leukocyte and malignant cell binding to vascular and lymphoid endothelial cells. CLEVER-1 is the first protein that has been reported to mediate both influx into and efflux from the lymph nodes. Also provided are methods of treating inflammation and preventing metastasis of malignant cells by providing an inhibitor of CLEVER-1 binding.

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Database EM-HUM Online, Accession No. HSD433, retrieved from EBI (created 1996, as updated Jul. 5, 2002).
Sequence comparison between Database EM-HUM Online, Accession No. HSD433, retrieved from EBI (Document No. AT1) (created 1996, as updated Jul. 5, 2002) with SEQ ID No. 1.
Database SWALL Online, Accession No. Q93072, retrieved from EBI (created 1997, as updated Jun. 1, 2003).
Sequence comparison between Database SWALL Online, Accession No. Q93072, retrieved from EBI (Document No. AS2) (created 1997, as updated Jun. 1, 2003) with the protein sequence of SEQ ID No. 1.
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Database EM-HUM Online, Accession No. HSA275213, retrieved from EBI (created 1999, as updated Feb. 14, 2003).
Sequence comparison between Database EM-HUM Online, Accession No. HSA275213, retrieved from EBI (Document No. AS3) (created 1999, as updated Feb. 14, 2003) with SEQ. ID. No. 1.
Database SWALL Online, Accession No. Q9NY15, retrieved from EBI (created 2000, as updated Jun. 1, 2003).
Sequence comparison between Database SWALL Online, Accession No. Q9NY15, retrieved from EBI (Document No. AR4) (created 2000, as updated Jun. 1, 2003) with the protein sequence of SEQ. ID. No. 1.
Database GSN Online, Accession No. AAA57362, retrieved from EBI (2000).
Sequence comparison between Database GSN Online, Accession No. AAA57362, retrieved from EBI (Document No. AT4) (2000) with SEQ. ID. No. 1 lacking nucleotides 2914-3009.
Sequence comparison between Database GSN Online, Accession No. AAA57362, retrieved from EBI (Document No. AT4) (2000) with SEQ. ID. No. 1.
Database GSP Online, Accession No. AAY93910, retrieved from EBI (2000).
Sequence comparison between Database GSP Online, Accession No. AAY93910, retrieved from EBI (Document No. AT5) (2000) with SEQ. ID. No. 1 lacking nucleotides 2914-3009.
Sequence comparison between Database GSP Online, Accession No. AAY93910, retrieved from EBI (Document No. AT5) (2000) with SEQ. ID. No. 1.
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Database SWALL Online, Accession No. Q93073, retrieved from EBI (created 1997, as updated Jul. 5, 2004).

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