Commercial process for the manufacture of fluconazole and interm

Details Commercial process for the manufacture of fluconazole and interm Commercial process for the manufacture of fluconazole and interm

1998-01-28

1999-02-16

Morris, Patricia L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

5482686, 5482688, C07D24908

Patent

active

058722580

ABSTRACT:
A process for making Fluconazole is provided comprising carrying out the following scheme of reaction: ##STR1##

REFERENCES:
patent: 4404216 (1983-09-01), Richardson
patent: 4612322 (1986-09-01), Ogata et al.
patent: 5484936 (1996-01-01), Veinbert et al.
Blundell et al., "Synthesis of Novel Azol Anti-Fungals by a Modified Sharpless Asymmetric Dihydroxylation", Synlett, Apr. 1994, pp. 263-165.
Gao, Y., "Vicinal Diol Cyclic Sulfates: Like Epoxides Only More Reactive", J. Am. Chem. Soc., 1988, vol. 110, pp. 7538-7539.
Lohray, B.B., "Cyclic Sulfites and Cyclic Sulfates: Epoxide like Synthons," Synthesis, Nov. 1994, pp. 1035-1052.
Sharpless, B. et al., "Catalytic Asymmetric Dihydroxylation", Chemical Reviews, 1994, vol. 94, No. 8, pp. 2484-2547.

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