Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Cosmetic – antiperspirant – dentifrice
Reexamination Certificate
2000-10-10
2003-05-13
Page, Thurman K. (Department: 1615)
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Cosmetic, antiperspirant, dentifrice
C424S045000, C424S063000, C424S070100, C424S070110, C424S070130, C424S450000, C424S489000, C424S065000
Reexamination Certificate
active
06562355
ABSTRACT:
BACKGROUND OF THE INVENTION
1. Technical Field of the Invention
The present invention relates to comixtures of dextran sulfate and escin for preventively or curatively treating skin redness and/or skin edema and/or sensitive skin, particularly redness and/or edema around the eyes and most particularly bags and/or dark rings around the eyes.
2. Description of the Prior Art
The human body in general is sensitive to the external attacking factors or challenges of modern life (exposure to UV radiation, large variations in hygrometry and temperature, pollution, etc.). The response to these challenges may be reflected, inter alia, by the appearance of redness associated with a local vasodilation or by the appearance of local edema.
In the field of skin disorders, it is known that certain skin types are more sensitive than others to external attacking factors.
The assignee hereof has now determined that the symptoms associated with sensitive skin are, in particular, subjective signs, which are essentially dysaesthetic sensations. By the expression “dysaesthetic sensations” are intended more or less painful sensations experienced in an area of skin, such as stinging, tingling, itching or pruritus, burning, heating, discomfort, tautness, etc., in response to various factors such as the environment, the emotions, foods, the wind, friction, shaving, soap, surfactants, hard water having a high calcium concentration, temperature variations, or wool.
Due to its structure and its high innervation, the area around the eyes is an anatomical region which is particularly sensitive to attacking factors or to behavioral mechanical stresses (friction). Following these stimuli and on account of a very low internal threshold of neurogenic sensitivity in certain more sensitive individuals, the area around the eyes rapidly shows evidence by redness and/or itching, which are the consequences of an exacerbated vasodilation, of a passing discomfort, but also by bags and/or dark rings and/or edema, of more persistent discomfort reflecting a greater metabolic depletion of the epidermis and the dermis.
Other than these physiological data, it is known that simply from their cosmetic appearance, redness, dark rings and bags have always been considered as unattractive and need continues to exist for means to mask or even eliminate same.
SUMMARY OF THE INVENTION
It has now surprisingly and unexpectedly been determined that comixture of dextran sulfate and escin elicits noteworthy calmant and/or vasodilation-inhibitory and/or anti-edema properties, these properties being developed in proportions which exceed the simple cumulation of the effects obtained with each of the components taken individually.
DETAILED DESCRIPTION OF BEST MODE AND SPECIFIC/PREFERRED EMBODIMENTS OF THE INVENTION
More particularly according to the present invention, dextran is a neutral polysaccharide with no charged moieties, which is biologically inert, and which is prepared by fermenting beet sugar containing only hydroxyl groups. It is possible to obtain dextran fractions of different molecular weights from native dextran by hydrolysis and purification. Too, dextran can be in the form of dextran sulfate.
Other than the physicochemical properties of dextran sulfate which are known to this art and which make it a good compound for cosmetic compositions (good solubility in water and saline solutions, high stability in solutions of pH ranging from 4 to 10 at room temperature), it is also known that dextran sulfate has properties of water absorption, a protective effect against the damage induced by free radicals, particularly in topical application, stabilization of proteins or unstable species and substances, and moisturization on account of its excellent hydrophilic properties. Biological properties such as an anti-coagulant effect, an inhibitory effect on enzymes such as hyaluronidase, glucosidases, elastase or even thrombin, and antiviral activity are also known.
As regards the skin and skin protection, dextran sulfate is known for its anti-wrinkle, anti-inflammatory, anti-allergic and anti-aging properties and for its role in treating rough and flaky skin and in moisturization.
Escin is a chemical molecule consisting of glucuronic acid and two sugars (glucose-xylose) linked to an aglycone, deglucoescin which has a molecular weight of 1131.24. This is a molecule which exists, for example, in plant extracts, particularly in extracts of common horsechestnut. In the prior art, escin is described in weight-reducing compositions (FR-2,729,856, EP-034,153, WO-97/42928 and WO-98/15259), in compositions for promoting blood circulation (EP-158,090 and U.S. Pat. No. 4,983,626), in compositions for treating the skin such as anti-inflammatory agents (EP-728,472), for improving the cohesion between the dermis and the epidermis (WO-98/19664) and in skin-lightening cosmetic compositions (JP-07,076,512).
It is also known to the prior art to formulate escin in compositions for treating bags and wrinkles under the eyes (FR-2,668,061, U.S. Pat. No. 5,273,916 and U.S. Pat. No. 5,571,503).
However, to date it is believed that the surprising synergistic effect exhibited by the intimate admixture of escin and dextran sulfate on the inhibition of the vasodilation and/or the anti-edema effect and/or the soothing of sensitive skin was unknown to this art.
Thus, the present invention features a comixture comprising, as active agent, formulated into a physiologically acceptable medium, intimate immixture of dextran sulfate and escin.
By the expression “physiologically acceptable medium” is intended a medium which is compatible with the skin, mucous membranes, the nails and the hair.
According to the invention, the composition preferably comprises dextran sulfate, in the form of a sodium salt thereof.
According to the invention, the dextran sulfate has a molecular weight ranging from 2×10
3
to 5×10
6
and preferably from 5×10
3
to 10
5
.
Too, the dextran sulfate can be of any origin. The compositions of the invention preferably comprise dextran sulfate marketed by Pharmacia Biotech under the trademark Dextran sulfate 10 sodium salt®.
The compositions of the invention comprise escin which can be of synthetic or natural origin.
By the expression “synthetic origin” is intended escin, in pure form or in solution, irrespective of its concentration in said solution, obtained by chemical synthesis. The expression “natural origin” connotes escin, in pure form or in solution, irrespective of its concentration in said solution , obtained from a natural element such as, for example, a plant extract, particularly an extract of common horsechestnut.
According to the invention, the composition preferably comprises escin marketed by the company Indena under the trademark escin 3030000® or, alternatively, escin marketed by the company LEK under the trademark amorphous beta Aescin®.
The amounts of dextran sulfate and of escin formulated into the compositions of the invention obviously depend on the desired effect.
For example, the amount by weight of dextran sulfate which are included in the compositions of the invention advantageously range, for example, from 0.01% to 5% and preferably from 0.05% to 2% relative to the total weight of the composition.
To provide an order of magnitude, the amount by weight of escin formulated according to the invention advantageously constitutes from 0.005% to 5% relative to the total weight of the composition, preferably from 0.01% to 2% relative to the total weight of the composition.
In the compositions of the invention, the weight ratio between the dextran sulfate and the escin advantageously ranges from 2×10
−3
to 10
3
and preferably from 25×10
−3
to 200.
Although they can be formulated for any application, the compositions of the invention are preferably formulated for topical application.
The compositions of the invention can be for cosmetic or dermatological applications. According to the invention, the composition is preferably a cosmetic composition and even more preferably a cosmetic composit
Burns Doane Swecker & Mathis L.L.P.
Page Thurman K.
Societe L'Oreal S.A.
Tran S.
LandOfFree
Comixture of dextran sulfate/escin for treating skin... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Comixture of dextran sulfate/escin for treating skin..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Comixture of dextran sulfate/escin for treating skin... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3034322