Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1998-01-07
2000-11-21
Shah, Mukund J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
548233, 548234, A61K 31421, C07D26308, A61P 304, A61P 310, A61P 1510
Patent
active
061503894
ABSTRACT:
A compound of formula I in which: ring A is one of the five alternative multi-cyclic rings as shown wherein a dotted line adjacent to a bond indicates that a single bond or a double bond may be present at that position; X is nitrogen, oxygen or sulfur; R is hydrogen, lower straight or branched chain alkyl of 1 to 6 carbon atoms, or lower straight or branched chain alkenyl of 2 to 6 carbon atoms, a cycloaliphatic ring of 3 to 6 carbon atoms, phenyl optionally mono- or di-substituted with hydroxy, halogen, alkyl of 1 to 3 carbon atoms or alkoxy of 1 to 2 carbon atoms, or methylenedioxyphenyl; or a stereoisomer, or a pharmaceutically acceptable salt thereof.
These compounds have .alpha..sub.2 receptor blocking activity and hence find use in the treatment or palliation of elevated intraocular pressure, non insulin-dependent diabetes, male impotence and obesity.
REFERENCES:
patent: 2870159 (1959-01-01), Bloom
patent: 2876232 (1959-03-01), Bloom
patent: 3108998 (1963-10-01), Poos
patent: 3133901 (1964-05-01), Poos
patent: 3278382 (1966-10-01), Poos
patent: 3432600 (1969-03-01), Harvey, Jr.
patent: 3453284 (1969-07-01), Harvey, Jr.
patent: 3509170 (1970-04-01), Leavitt
patent: 3514486 (1970-05-01), Hartzler
patent: 3598833 (1971-08-01), Hiltmann
patent: 3624092 (1971-11-01), Levitt
patent: 3636219 (1972-01-01), Culik
patent: 3679798 (1972-07-01), Culik et al.
patent: 4064348 (1977-12-01), Peet et al.
patent: 4256755 (1981-03-01), Smith
patent: 4515800 (1985-05-01), Cavero et al.
patent: 4587257 (1986-05-01), De Santis et al.
patent: 4590202 (1986-05-01), Remy
patent: 4980364 (1990-12-01), Goodman
patent: 5066664 (1991-11-01), Gluchowski
patent: 5091528 (1992-02-01), Gluchowski
patent: 5580892 (1996-12-01), Garst
patent: 5731337 (1998-03-01), Munk et al.
patent: 5837751 (1998-11-01), Jacobine et al.
Poos, et al, Journal of Organic Chemistry, 1961, 26, 4898-4904, "Bicyclic Bases. III. Isomeric 2-Amino-3-phenylnorbornanes .sup.1 ".
Registry No. 101 832-33-1 (1986).
Banert et al, Journal of the American Chemical Society, 1982, 104, pp. 3766-3767, "Sn2 Displacements at 2-Norbornyl Brosylates".
Burke James A.
Garst Michael E.
Munk Stephen A.
Allergan Sales Inc.
Baran Robert J.
Coleman Brenda
Fisher Carlos A.
Shah Mukund J.
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