Combretastatin analogs with tubulin binding activity

Details Combretastatin analogs with tubulin binding activity Combretastatin analogs with tubulin binding activity

2006-06-14

2008-09-30

Eyler, Yvonne (Department: 1621)

Organic compounds -- part of the class 532-570 series

Organic compounds

Oxygen containing

C514S678000

Reexamination Certificate

active

07429681

ABSTRACT:
Analogs of combretastatin have been discovered which demonstrate impressive cytotoxicity as well as a remarkable ability to inhibit tubulin polymerization. Such compounds are excellent clinical candidates for the treatment of cancer in humans. In addition, certain of these ligands, as pro-drugs, may well prove to be tumor selective vascular targeting chemotherapeutic agents or to have vascular targeting activity resulting in the selective prevention and/or destruction of nonmalignant proliferating vasculature.

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