Combretastatin A-4 phosphate prodrug mono- and di-organic...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Phosphorus containing other than solely as part of an...

Reexamination Certificate

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Details

C558S194000, C558S210000, C558S211000

Reexamination Certificate

active

07659262

ABSTRACT:
Provided herein are novel and useful combretastatin A-4 prodrug salts that increase the solubility of combretastatin A-4, readily regenerate combretastatin A-4 in vivo under normal physiological conditions, and which produce physiologically tolerable products as a result of the regeneration of combretastatin A-4.

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patent: 2006/0166942 (2006-07-01), Venit et al.
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patent: WO 00/48590 (2000-08-01), None
patent: WO 00/48591 (2000-08-01), None
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Grant et al, Grant & Hackh's Chemical Dictionary , 1987, p. 285 (2 pages ).
Berge et al , Journal of Pharmaceutical Sciences, vol. 66, No. 1, 1977, p. 1-18.
Pettit, George R. “Antineoplastic agents 393. Synthesis of the trans-isomer of combretastatin A-4 prodrug” Anti-Cancer Drug Design. 1998;13:981-993.
International Search Report for International Application No. PCT/US01/28401.

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