Combretastatin A-4

Details Combretastatin A-4 Combretastatin A-4

1988-02-22

1991-02-26

Rollins, John W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ether doai

514721, 568631, 568646, A61K 31075

Patent

active

049962370

ABSTRACT:
The African tree Combretum caffrum (Combretaceae) has been found to contain an agent which is a powerful inhibitor of tubulin polymerization (IC50 2-3 .mu.M), the growth of murine lymphocytic leukemia (L1210 and P388 with ED50 <0.003 mg/ml and human colon cancer cell lines (e.g. VoLo with ED50 <0.01 .mu.g/ml). This agent is herein denominated "combretastatin A-4". The structure assigned by spectral techniques was confirmed by synthesis.

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