Combined use of interleukin 10 and cyclosporin for immunosuppres

Details Combined use of interleukin 10 and cyclosporin for immunosuppres Combined use of interleukin 10 and cyclosporin for immunosuppres

1996-08-09

2000-02-08

Draper, Garnette D.

Drug, bio-affecting and body treating compositions

Lymphokine

Interleukin

514 2, 514 8, 514 12, 514 21, 514885, A61K 3819

Patent

active

06022536&

ABSTRACT:
A combination of interleukin 10 and cyclosporin is used to suppress graft-versus-host disease, autoimmune diseases and tissue/graft rejection. It has been discovered that administration of a combination of interleukin 10 and cyclosporin causes synergistic suppression of T cell proliferation. Concurrent use of both agents avoids the toxicity associated with higher doses of cyclosporin.

REFERENCES:
patent: 4117118 (1978-09-01), Harri et al.
patent: 4996193 (1991-02-01), Hewitt et al.
patent: 5013719 (1991-05-01), Bowlin
patent: 5328989 (1994-07-01), Vellekamp et al.
patent: 5430017 (1995-07-01), Antalne et al.
patent: 5543393 (1996-08-01), Kim et al.
Tadmori et al., 1994, Cytokine, 6:462-471.

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