Combined use of an antigestagen and a progesterone synthesis inh

Details Combined use of an antigestagen and a progesterone synthesis inh Combined use of an antigestagen and a progesterone synthesis inh

1995-02-09

1998-08-18

Jordan, Kimberly

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Cyclopentanohydrophenanthrene ring system doai

514171, 514172, 514179, A61K 3156, A61K 3158

Patent

active

057958815

ABSTRACT:
A pharmaceutical agent contains a progesterone synthesis inhibitor (ProI) of the trilostane or epostane type and an antigestagen (AG). It can be used for inducing delivery at term in humans and animals, for terminating normal or pathological pregnancies therein or for treatment of hormone-dependent tumors, endometriosis or dysmenorrhea.

REFERENCES:
patent: 4062954 (1977-12-01), Potts
patent: 4160027 (1979-07-01), Christiansen
patent: 4626531 (1986-12-01), Elger et al.
patent: 4670426 (1987-06-01), Zor et al.
Chemical Abstracts, vol. 101, 1984 ; pp. 80.
Webster's Third New International Dictionary of the English Language, Unabridged, 1976, p. 1246.
"Studies on Interactions of Antiprogestins with Prostaglandins and . . . ", W. Elger et al., Hormone Antagonists for Fertility Reg., 1988, pp. 105-114.
"Effect of Epostane, ZK 98299, and ZK 98734 on the Interruption of . . . ", B.W. Snyder et al., Biol. of Repro., 40, 1989, pp. 549-554.
Physician'Desk Ref., 48th ed., 1994, pp. 539-540, 1072-1074 and 1651.

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