Combined treatment with GnRH antagonist and GnRH to control gona

Details Combined treatment with GnRH antagonist and GnRH to control gona Combined treatment with GnRH antagonist and GnRH to control gona

1990-06-14

1993-01-19

Lee, Lester L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

530328, A61K 3702, A61K 3738, C07K 706

Patent

active

051807114

ABSTRACT:
The present invention relates to a method of controlling gonadotropin levels in mammals which comprises administering a gonadotropin releasing hormone (GnRH) antagonist in an amount and frequency effective to substantially suppress endogenous gonadotropin levels in said mammal and administering gonadotropin releasing hormone (GnRH) in an amount and frequency effective to induce secretion of gonadotropins to maintain a desired level in said mammal. This method is especially useful for treating mammals, particularly women, who suffer from polycystic ovarian disease or hyperandrogenism, or who otherwise have abnormally high levels of luteinizing hormone which it is desired to reduce to approximately normal levels. The method of this invention is particularly advantageous for inducing ovulation in mammals, particularly women, that have the above-mentioned problems. The preferred GnRH antagonists for use in the present invention include Antide and its analogs, which exhibit long term gonadotropin suppression.

REFERENCES:
patent: 4845077 (1989-07-01), Hodgen
Metrodin-The Gonadotropins in the Polycystic Ovarian Disease, product brochure of the Ares-Serono Group, 1990.
Coutts, Excerpta-Medica Int'l Congress Series 652:608 (1984).
Leal, Contraception 40:623, 1989.
Kenigsberg, J. Clin. Endocrinol. Metab. 62:734, 1986.
Chillik, Fertility and Sterility 48:480, 1987.

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