Drug – bio-affecting and body treating compositions – Lymphokine – Interferon
Patent
1993-03-08
2000-08-01
Sayala, Chhaya D.
Drug, bio-affecting and body treating compositions
Lymphokine
Interferon
424 854, 424 857, 514648, 514651, 514874, 564324, A61K 3821
Patent
active
060963018
ABSTRACT:
Proliferation of breast cancer is treated by a combined type I interferon
on-steroidal antiestrogen therapy. Preferably antiestrogen treatment is sequential to treatment with interferon.
REFERENCES:
patent: 4992271 (1991-02-01), Fernandes et al.
patent: 4994556 (1991-02-01), Mitsuhashi et al.
"Cancer of the Female Breast International Mortality Trends" by W.P.D. Logan, W.H.O. Stat. Rep., vol. 28, p. 232, 1975.
"Effects of Human Interferon Alpha-2 and Gamma on Proliferation Estrogen Receptor Content and Sensitivity to Anti-Estrogens of Cultured Breast Cancer Cells" by Ch. Marth et al., vol. 24, Serono Symposia Publications from Raven Press, 1985.
"Two New Estrogen-Supersensitive Variants of the MCF-7 Human Breast Cancer Cell Line" by C. Natoli et al., Breast Cancer Research and Treatment 3, 23-32 (1983).
Kangas, et al., Additive and Synergistic Antitumor Effects with Toremifene and Interferons, J. Steroid Biochem., 36(3) p. 259-62 (1990).
Dimitrov N. V. et al., Interferon As A Modifier Of Estrogen Receptor, Ann. Clin. Lab. Sci. 14:32-39 (1984).
van den Berg, H. W. et al., The British Journal of Cancer, 52 (3) : 248, 1987.
Kangas, L et al., "Additive & synergistic effects of a novel anti-estrogen, toremifene . . . ", Med Biol., 63(4), 1985, p. 187-90 (Medline abstract).
Mitchell, M.S., "Breast cancer treatment--current status", Postgrad. Med., 74(3), 161-5,168-72,174-5, (1983 Sep.) (Medline abstract).
Yuang Chi Chang, et al., J. Interferon Res., vol. 3(3), p. 299-304 (1983). (Embase abstract).
Sherwin, S.A. et al., "Recombinant leukocyte A inteferon . . . ", Ann. Intern. Med., vol. 98(5), 1983, pp. 598-602. (Embase abstract).
The Merck Index, An Encyclopedia of Chemicals, Drugs & Biologicals, Eleventh Edition, 1989, pp. 9473 & 9017.
Porzsolt et al., J. Cancer Res. Clin Oncol., vol. 115, pp. 465-469, 1989.
"Rationale For Combining Tamoxifen And Interferon In The Treatment Of Advanced Breast Cancer" by F. Porzsolt et al., J. Cancer Res. Clin. Oncol. (1989) 115:465-469.
Abstracts of 1985 TNO-ISIR meeting on Interferon System on Oct. 13-18, 1985 Sica et al., "Proliferative Effect of Beta-Interferon (Frone) Alone or Combined with Tamoxifen (TAM) in Breast Cancer Cells".
H. W. van den Berg et al., BR.J. Cancer, 55:255, 1987.
Sica et al., Anticancer Res. 6(3 Part A) (Apr. 1986) p. 396.
"Antiestrogens In The Treatment Of Breast Cancer" by Sewa S. Legha et al., Cancer Treatment Reviews (1976) 3, 205-216.
"Endocrine Factors In Breast Cancer", J.C. Allegra, Reviews on Endocrine-Related Cancer (1984), Suppl. 14, 115.
"Comparative Antiproliferative Activity in Vitro of Natural Interferons .alpha. and .beta. for Diploid and Transformed Human Cells" by E.C. Borden et al., Cancer Reseach 42, 4948-4953, Dec. 1982.
"Antiproliferative Effect of Natural Beta Interferon on Fresh Tumor Cells Analyzed in a Clonogenic Assay" by David R. Strayer et al., Journal of Interferon Research, 4:627-633 (1984).
"Administration of Fibroblast Interferon to Patients with Advanced Breast Cancer: Possible Effects on Skin Metastasis and on Hormone Receptors" by P. Pouillart et al. Eur. J. Cancer Clin. Oncol. vol. 18, No. 10, pp. 929-935, 1982.
Bianco Sergio Del
Sica Gigliola
Industria Farmaceutica Serono SpA
Sayala Chhaya D.
LandOfFree
Combined interferon/antiestrogen therapy for treatment of breast does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Combined interferon/antiestrogen therapy for treatment of breast, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Combined interferon/antiestrogen therapy for treatment of breast will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-660958