Combined Haemophilus influenzae type b and pertussis vaccine

Details Combined Haemophilus influenzae type b and pertussis vaccine Combined Haemophilus influenzae type b and pertussis vaccine

1977-10-28

1980-04-01

Rosen, Sam

Drug, bio-affecting and body treating compositions

Whole live micro-organism, cell, or virus containing

Genetically modified micro-organism, cell, or virus

A61K 3902

Patent

active

041961927

ABSTRACT:
A process for the isolation and purification of immunologically active polyribosyl ribitol phosphate (PRP), the capsular polysaccharide of Haemophilus influenzae type b. The PRP has been purified with ethanol, Cetavlon (hexadecyltrimethyl ammonium bromide) and a phosphate containing adsorbent, hydroxylapatite. The contaminants (nucleic acid, proteins and endotoxins) are removed to the minimum level by a treatment with hydroxylapatite. Also described is a process for the preparation of a combined vaccine containing the PRP (prepared as aforementioned) and B. pertussis antigens. The vaccine elicits anti-PRP antibody and antipertussis antibody (as measured by microagglutination) formations in young animals. This sera with anti-PRP antibody exhibits a strong bactericidal activity.

REFERENCES:
patent: 4029766 (1977-06-01), Helting
Chem. Abst. 8th Coll. Index, vol. 66-75. (1967-1971), p. 1874 GS.
Branefors-Helander et al., Chem. Abst. vol. 84, (1976), p. 162787y.
d'Hinterland et al., Chem. Abst. vol. 83, (1975), p. 152,329r.
Anderson et al., J. of Infect. Diseases, vol. 136 (Aug. 1977), p. 857.
Sell et al., Antimicrobial Agents and Chemotherapy, (Oct. 1976), article 192.
Moxon et al., Bull. W.H.O., vol. 52, (1975), pp. 87-90.

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