Combined growth factor-deleted and thymidine kinase-deleted...

Chemistry: molecular biology and microbiology – Vector – per se

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C514S04400A

Reexamination Certificate

active

09991721

ABSTRACT:
A composition of matter comprising a vaccinia virus expression vector with a negative thymidine kinase phenotype and a negative vaccinia virus growth factor phenotype.

REFERENCES:
patent: 5236838 (1993-08-01), Rasmussen et al.
patent: 5622835 (1997-04-01), Herlyn et al.
patent: 5739027 (1998-04-01), Kamb
patent: 5744133 (1998-04-01), Lathe et al.
patent: 5851991 (1998-12-01), Lee et al.
patent: 5942235 (1999-08-01), Paoletti
patent: 5962260 (1999-10-01), Sawamura et al.
patent: 5981714 (1999-11-01), Cheng et al.
patent: 6093700 (2000-07-01), Mastrangelo et al.
patent: 6103244 (2000-08-01), Dorner et al.
patent: 3411472 (1984-10-01), None
patent: 0 443 335 (1991-08-01), None
patent: 0 585 960 (1994-09-01), None
patent: 55026477 (1980-02-01), None
patent: 402065779 (1990-03-01), None
patent: WO 92/15672 (1992-09-01), None
patent: WO 94/16716 (1994-08-01), None
patent: WO 94/10575 (1994-11-01), None
patent: WO 95/31105 (1995-11-01), None
patent: WO 98/08394 (1998-05-01), None
Kaplan C. Vaccinia virus: a suitable vehicle for recombinant vaccines? Arch Virol. 1989;106(1-2):127-39.
Zhang et al. An enhanced green fluorescent protein allows sensitive detection of gene transfer in mammalian cells. Biochem Biophys Res Commun. Oct. 23, 1996;227(3):707-11.
UniProtKB/Swiss-Prot Database entry P04637, P53—HUMAN.
Advani, S. J., et al. (1999) Replication-competent, Nonneuroinvasive Genetically Engineered Herpes Virus Is Highly Effective in the Treatment of Therapy-resistant Experimental Human Tumors. Cancer Res. 59:2055-2058.
Beer, S. J., et al. (1998) Poly (lactic-glycolic) acid copolymer encapsulation of recombinant adenovirus reduces immunogenicity in vivo. Gene Ther. 5:740-746.
Buller, R. M. L., et al. (1988) Deletion of the Vaccinia Virus Growth Factor Gene Reduces Virus Virulence. J. Virol. 62(3):866-874.
Buller, R. M. L., et al. (1988) Cell Proliferative Response to Vaccinia Virus Is Mediated by VGF. Virology 164:182-192.
Buller, R. M., et al. (1985) Decreased virulence of recombinant vaccinia virus expression vectors is associated with a thymidine kinase-negative phenotype. Nature 317:813-815.
Carroll, M. W. and Moss, B. (1997) Poxviruses as expression vectors. Curr. Opin. Biotechnol. 8:573-577.
Chakrabarti, S., et al. (1997) Compact, Synthetic, Vaccinia Virus Early/Late Promoter for Protein Expression. BioTechniques 23:1094-1097.
Chase, M., et al. (1998) An oncolytic viral mutant that delivers theCYP2B1transgene and augments cyclophosphamide chemotherapy. Nat. Biotech. 16:444-448.
Chillon, M., et al. (1998) Adenovirus complexed with polyethylene glycol and cationic lipid is shielded from neutralizing antibodies in vitro. Gene Ther. 5:995-1002.
Davison, A. J. and Moss, B. (1989) Structure of Vaccinia Virus Late Promoters. J. Mol. Biol. 210:771-784.
Davison, A. J. and Moss, B. (1989) Structure of Vaccinia Virus Early Promoters. J. Mol. Biol. 210:749-769.
Dmitriev, I., et al. (1998) An Adenovirus Vector with Genetically Modified Fibers Demonstrates Expanded Tropism via Utilization of a Coxsackievirus and Adenovirus Receptor-Independent Cell Entry Mechanism. J. Virol. 72(12):9706-9713, 1998.
Flexner, C., et al. (1990) Attenuation and immunogenicity in primates of vaccinia virus recombinants expressing human interleukin-2. Vaccine 8:17-21.
Galmiche, M. C., et al. (1997) Expression of a functional single chain antibody on the surface of extracellular enveloped vaccinia virus as a step towards selective tumour cell targeting. J. Gen. Virol. 78:3019-3027.
Gnant, M. F. X., et al. (1999) Systemic Administration of a Recombinant Vaccinia Virus Expressing the Cytosine Deaminase Gene and Subsequent Treatment with 5-Fluorocytosine Leads to Tumor-specific Gen Expression and Prolongation of Survival in Mice. Cancer Res. 59:3396-3403.
Gnant, M. F. X., et al. (1999) RegionalVersusSystemic Delivery of Recombinant Vaccinia Virus as Suicide Gene Therapy for Murine Liver Metastases. Ann. Surg. 230(3):352-361.
Goede, V., et al. (1998) Analysis of Blood Vessel Maturation Processes during Cyclic Ovarian Angiogenesis. Lab. Investig. 78(11):1385-1394.
Gurvich, E. B. and Vilesova, I. S. (1983) Vaccinia Virus in Postvaccinal Encephalitis. Acta. Virol. 27:154-159.
Heise, C., et al. (1997) ONYX-015, and E1B gene-attenuated adenovirus, causes tumor-specific cytollysis and antitumoral efficacy that can be augmented by standard chemotherapeutic agents. Nat. Med. 3(6):639-645.
Hodge, J. W., et al. (1994) Induction of Antitumor Immunity by Recombinant Vaccinia Viruses Expressing B7-1 or B7-2 Costimulatory Molecules. Cancer Res. 54:5552-5555.
Kantor, J., et al. (1992) Immunogenicity and Safety of a Recombinant Vaccinia Virus Vaccine Expressing the Carcinoembryonic Antigen Gene in a Nonhuman Primate. Cancer Res. 52:6917-6925.
Kaplan, E. L. and Meier, P. (1958) Nonparametric Estimation From Incomplete Observations. Am. Stat. Assoc. J. 53:457-481.
Karupiah, G., et al. (1990) Vaccinia virus-mediated damage of murine ovaries and protection by virus-expressed interleukin-2. Immunol. Cell Biol. 68:325-333.
Keane, J. T., et al. (1983) Progressive Vaccinia Associated With Combined Variable Immunodeficiency. Arch. Dermatol. 119:404-408.
Kim, C. J., et al. (1998) Use of Recombinant Proxviruses to Stimulate Anti-Melanoma T Cell Reactivity. Ann. Surg. Oncol. 5(1):64-76.
Kim, D. H., and McCormick, F. (1996) Replicating viruses as selective cancer therapeutics. Mol. Med. Today 2:519-527.
Kohn, S., et al. (1992) Pathways of Macromolecular Tracer Transport Across Venules and Small Veins. Lab. Investig. 67(5):596-607.
Lane, J. M. and Millar, J. D. (1971) Risks of Smallpox Vaccination Complications in the United States. Am. J. Epidemiol. 93(4):238-240.
Mantel, N. (1966) Evaluation of Survival Data and Two New Rank Order Statistics Arising in its Consideration. Cancer Chemother. Reps. 50(3):163-170.
Martuza, R. L., et al. (1991) Experimental Therapy of Human Glioma by Means of a Genetically Engineered Virus Mutant. Science 252:854-856, 1991.
Mastrangelo, M. J., et al. (2000) Intralesional Vaccinia/GM-CSF Recombinant Virus in the Treatment of Metastatic Melanoma. Adv. Exp. Med. Biol. 465:391-400.
Mastrangelo, M. J. et al. (1998) Intratumoral recombinant GM-CSF-encoding virus as gene therapy in patients with cutaneous melanoma. Cancer Gene Ther. 6(5):409-422.
McAneny, D., et al. (1996) Results of a Phase I Trial of a Recombinant Vaccinia Virus That Expresses Carcinoembryonic Antigen in Patients with Advanced Colorectal Cancer. Ann. Surg. Oncol. 3(5):495-500.
McCart, J. A., et al. (2001) Systemic Cancer therapy with a Tumor-selective Vaccinia Virus Mutant Lacking Thymidine Kinase and Vaccinia Growth Factor Genes. Cancer Res. 61:8751-8757.
McCart, J. A., et al. (2000) Complex interactions between the replicating oncolytic effect and the enzyme/prodrug effect of vaccinia-mediated tumor regression. Gene Ther. 7:1217-1223.
Meko, J. B., et al. (1995) High Cytokine Production and Effective Antitumor Activity of a Recombinant Vaccinia Virus Encoding Murine Interleukin 12. Cancer Res. 55:4765-4770.
Moss, B. (1996) Genetically engineered poxviruses for recombinant gene expression, vaccination, and safety. PNAS USA 93:11341-11348.
Mukherjee, S., et al. (2000) Replication-restricted vaccinia as a cytokine gene therapy vector in cancer: Persistent transgene expression despite antibody generation. Cancer Gene Ther. 7(5):663-670.
O'Reilly, M. S., et al. (1997) Endostatin: an Endogenous Inhibitor of Angiogenesis and Tumor Growth. Cell 88:277-285.
Overwijk, W., et al. (1999)Vaccination with a recombinant vaccinia virus encoding a “self” antigen induces autoimmune vitiligo and tumor cell destruction in mice: Requirement of CD4+ T lymphocytes. PNAS USA 96:2982-2987.
Palumbo, G. J., et al. (1998) A Replication Competent Recombinant Vaccinia Vector Expressing HSV-TK for the Treatment of Tumorsin Vivo. Am. Soc. Gene Ther. 1:169a.
Park, B. J., et al. (1999) Augmentation of Melanoma-Specific Gene Expression Using a Tandem Melanocyte-Specific Enhancer Results in Increased Cytotoxicity of the Purine Nucleoside Phosphorylase Gene in Melanoma. Hum

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Combined growth factor-deleted and thymidine kinase-deleted... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Combined growth factor-deleted and thymidine kinase-deleted..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Combined growth factor-deleted and thymidine kinase-deleted... will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3731052

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.