Chemistry: electrical and wave energy – Processes and products – Electrostatic field or electrical discharge
Patent
1993-08-02
1995-06-13
Niebling, John
Chemistry: electrical and wave energy
Processes and products
Electrostatic field or electrical discharge
204299R, 250288, G01N 2726, G01N 27447, H01J 4904
Patent
active
054239648
ABSTRACT:
An improvement to the system and method for analyzing molecular constituents of a composition sample that comprises improvements to an electrospray ionization source for interfacing to mass spectrometers and other detection devices. The improvement consists of establishing a unique electrical circuit pattern and nozzle configuration, a metallic coated and conical shaped capillary outlet, coupled with sizing of the capillary to obtain maximum sensitivity.
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Richard D. Smith, Charles J. Barinaga, and Harold R. Udseth, "Improved Electrospray Ionization Interface for Capillary Zone Electrophoresis-Mass Spectrometry" Analytical Chemistry vol. 60 No. 18, (Sep. 1988) 1948-1952.
Richard D. Smith, Harold R. Udseth, Charles J. Barinaga, Charles G. Edmonds "Instrumentation for high-performance capillary electrophoresis-mass spectrometry" Journal of Chromatography, 559 (1991) 197-208.
"Attomole Level Capillary Electrophoresis-Mass Spectrometric Protein Analysis Using 5 .mu.m i.d. Capillaries", J. H. Wahl, D. R. Goodlett, H. R. Udseth, R. D. Smith, Anal. Chem., 64, 3194-3196 (Dec. 1992).
"Use of Small-Diameter Capillaries for Increasing Peptide and Protein Detection Sensitivity in Capillary Electrophoresis-Mass Spectrometry," J. H. Wahl, D. R. Goodlett,H. R. Udseth, R. D. Smith, Electrophoresis, 14, 448-457 (1993).
"Capillary Electrophoresis-Mass Spectrometry," R. D. Smith, J. H. Wahl, D. R. Goodlett, and S. A. Hofstadler, Anal. Chem., 65, 574A-584A (Jul. 1993).
"Sheathless Capillary Electrophoresis-Electrospray Ionization/Mass Spectrometry using 10 .mu.m i.d. Capillaries: Analysis of Tryptic Digests of Cytochrome c," J. H. Wahl, D. C. Gale, and R. D. Smith, J. Chromatography.
Barinaga Charles J.
Smith Richard D.
Udseth Harold R.
Battelle (Memorial Institute)
Hynson Johnnie R.
Niebling John
Starsiak Jr. John S.
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