Combined cellular and immunosuppressive therapies

Details Combined cellular and immunosuppressive therapies Combined cellular and immunosuppressive therapies

1994-09-28

1997-09-23

Ziska, Suzanne E.

Drug, bio-affecting and body treating compositions

Whole live micro-organism, cell, or virus containing

Genetically modified micro-organism, cell, or virus

4351923, 424933, 424937, 424572, C12N 1500, A01N 6300, A61K 3512

Patent

active

056701489

ABSTRACT:
Novel regimens are provided for administering foreign genetically modified allogeneic cells to a host by combining the administration of the cells with a reduced regimen of an immunosuppressive agent. Particularly, cells having a reduced level of Class I MHC antigens may be employed in a variety of cellular therapy situations, where foreign cells are engrafted to treat diseased states.

REFERENCES:
patent: 4980286 (1990-12-01), Morgan
patent: 5175004 (1992-12-01), Matsumura
E. Alamartine et al., "The influence of prophylactic immunosuppressive regimens on natural killer and lymphokine-activated killer cells in renal transplant recipients", Transplantation, 50:969-973 (1990).
M. Bix et al., "Rejection of class I MHC deficient haemapooietic cells by irradiated MHC-matched mice", Nature, 349:329-331 (1991).
Dupuy et al, "Cyclosporine A inhibits the antigen-presenting functions of freshly isolated human hangerhans cells in vitro", J. Inves. Dermatology, 96(4):408-413 (1991).
Kosugi and Shearer, "Effect of cyclosporine A on lymphopoiesis", J. Immunol., 146:1416-1421 (1991).
N. Liao et al., "MHC class I deficiency: susceptibility to natural killer (NK) cells and impaired NK activity", Science, 253:199-202 (1991).
C. Ohlen et al, "Prevention of allogeneic bone marrow graft rejection by H-2 transgene in donor mice", Science, 246:666-668 (1989).

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