Combined antiviral and antimediator treatment of common colds

Details Combined antiviral and antimediator treatment of common colds Combined antiviral and antimediator treatment of common colds

1991-11-19

1993-08-31

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Effervescent or pressurized fluid containing

Organic pressurized fluid

424405, 424408, 424434, 424435, 424451, 424464, 424489, A01N 2534, A61K 914, A61K 948, A61L 904

Patent

active

052406946

ABSTRACT:
The common cold is best treated by providing a combination of antiviral agents and antiinflammatory compounds to a patient infected with a cold virus. An antiviral agent and two antiinflammatory compounds given to a person infected with a cold virus simultaneously reduces the likelihood of a cold developing and the amount and duration of viral shedding, as well as substantially reduces the severity of individual cold symptoms and the overall number and severity of cold symptoms. Supplementing the activity of the combined antiviral and antiinflammatory agents with such compounds as antihistamines and alpha agonists results in suprisingly good nasal benefits. The combination therapy, termed COVAM therapy, is well tolerated and has no evidence of short-term toxicity.

REFERENCES:
patent: 4269842 (1991-05-01), Farge et al.
patent: 5137876 (1992-09-01), MacCoss et al.
Gwaltney, "Combined Antiviral and Antimediator Treatment of Rhinovirus Colds", J. Infect. Dis, 166:776-82 (1992).
Hayden et al., J. Infect. Dis., 150:174-180 (1984).
Gaffey et al., Antimicrob. Agents Chemotherap., 32:1644-7 (1988).
Sperber et al., Annls. Int. Med., 117:37-41 (1992).

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