Combinatorial synthesis system

Chemical apparatus and process disinfecting – deodorizing – preser – Control element responsive to a sensed operating condition

Reexamination Certificate

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C422S050000, C422S051000, C422S051000, C422S051000, C422S067000, C422S068100, C422S081000, C422S082000, C422S082010, C422S082020, C422S082050, C422S105000, C422S105000, C422S105000, C422S105000, C436S174000, C436S178000, C436S180000, C436S063000, C436S002000, C436S008000, C436S068000, C436S501000, C436S066000

Reexamination Certificate

active

07097809

ABSTRACT:
The present invention provides a microfluidic device for synthesizing an array of compounds and methods for using the same. In particular, the microfluidic device of the present invention comprises a solid support base, an elastomeric layer attached to the solid support, and a plurality of flow channels located within the interface between the solid support and the elastomeric layer. In addition, the solid support comprises a functional group for forming a bond with a reactive reagent. In some embodiments, the microfluidic device further comprises a second plurality of flow channels that intersect the first plurality of flow channels. A plurality of control channels are also present in the microfluidic devices of the present invention. The control channels can be actuated to regulate flow of fluids within the flow channel(s).

REFERENCES:
patent: 3570515 (1971-03-01), Kinner
patent: 3747628 (1973-07-01), Holster et al.
patent: 4046159 (1977-09-01), Pegourie
patent: 4119368 (1978-10-01), Yamazaki
patent: 4153855 (1979-05-01), Feingold
patent: 4245673 (1981-01-01), Bouteille et al.
patent: 4434704 (1984-03-01), Surjaatmadja
patent: 4898582 (1990-02-01), Faste
patent: 4992312 (1991-02-01), Frisch
patent: 5085562 (1992-02-01), Van Lintel
patent: 5088515 (1992-02-01), Kamen
patent: 5096388 (1992-03-01), Weinberg
patent: 5126115 (1992-06-01), Fujita et al.
patent: 5164558 (1992-11-01), Huff et al.
patent: 5171132 (1992-12-01), Miyazaki et al.
patent: 5224843 (1993-07-01), Van Lintel
patent: 5259737 (1993-11-01), Kamisuki et al.
patent: 5265327 (1993-11-01), Faris et al.
patent: 5290240 (1994-03-01), Horres, Jr.
patent: 5336062 (1994-08-01), Richter
patent: 5346372 (1994-09-01), Naruse et al.
patent: 5375979 (1994-12-01), Trah
patent: 5376252 (1994-12-01), Ekström et al.
patent: 5400741 (1995-03-01), DeTitta et al.
patent: 5423287 (1995-06-01), Usami et al.
patent: 5529465 (1996-06-01), Zengerle et al.
patent: 5593130 (1997-01-01), Hansson et al.
patent: 5642015 (1997-06-01), Whitehead et al.
patent: 5659171 (1997-08-01), Young et al.
patent: 5660370 (1997-08-01), Webster
patent: 5681024 (1997-10-01), Lisec et al.
patent: 5681484 (1997-10-01), Zanzucchi et al.
patent: 5705018 (1998-01-01), Hartley
patent: 5759014 (1998-06-01), Van Lintel
patent: 5775371 (1998-07-01), Pan et al.
patent: 5788468 (1998-08-01), Dewa et al.
patent: 5836750 (1998-11-01), Cabuz
patent: 5842787 (1998-12-01), Kopf-Sill et al.
patent: 5858188 (1999-01-01), Soane et al.
patent: 5866345 (1999-02-01), Wilding et al.
patent: 5875817 (1999-03-01), Carter
patent: 5876187 (1999-03-01), Afromowitz et al.
patent: 5885837 (1999-03-01), Winkler et al.
patent: 5922591 (1999-07-01), Anderson et al.
patent: 5932799 (1999-08-01), Moles
patent: 5942443 (1999-08-01), Parce et al.
patent: 6007309 (1999-12-01), Hartley
patent: 6043080 (2000-03-01), Lipshutz et al.
patent: 6123769 (2000-09-01), Sanjoh
patent: 6155282 (2000-12-01), Zachary et al.
patent: 6174365 (2001-01-01), Sanjoh
patent: 6186660 (2001-02-01), Kopf-Sill et al.
patent: 6261431 (2001-07-01), Mathies et al.
patent: 6264892 (2001-07-01), Kaltenbach et al.
patent: 6296673 (2001-10-01), Santarsiero et al.
patent: 6345502 (2002-02-01), Tai et al.
patent: 6408878 (2002-06-01), Unger et al.
patent: 6409832 (2002-06-01), Weigl et al.
patent: 6454924 (2002-09-01), Jedrzejewski et al.
patent: 6767706 (2004-07-01), Quake et al.
patent: 2001/0027745 (2001-10-01), Weigl et al.
patent: 2002/0037499 (2002-03-01), Quake et al.
patent: 0 592 094 (1994-04-01), None
patent: 0 703 364 (1996-03-01), None
patent: 0 706 004 (1996-04-01), None
patent: 0 779 436 (1997-06-01), None
patent: 0 829 360 (1998-03-01), None
patent: 0 845 603 (1998-06-01), None
patent: 0 999 055 (2000-05-01), None
patent: 2 155 152 (1985-09-01), None
patent: 2 308 460 (1997-06-01), None
patent: WO 98/07069 (1998-02-01), None
patent: WO 99/00655 (1999-01-01), None
patent: WO 99/04361 (1999-01-01), None
patent: WO 99/17093 (1999-04-01), None
patent: WO 99/52633 (1999-10-01), None
patent: WO 00/00678 (2000-01-01), None
patent: WO 00/43748 (2000-07-01), None
patent: WO 00/60345 (2000-10-01), None
patent: WO 01/09595 (2001-02-01), None
patent: WO 01/09595 (2001-02-01), None
E. M. Southern et al.,Geonomics,1992, 13, 1008-1017.
Edwin M. Southern et al.,Journal of Biotechnology,1994, 35, 217-227.
G. Wallraff et al.,Chemtech,1997, 22-32.
R. Michael van Dam et al.,Genome Research,145-152.
Ahn et al., “Fluid Micropumps Based on Rotary Magnetic Actuators,” Proceedings of 1995 IEEE Micro Electro Mechanical Systems Workshop (MEMS '95), held in Amsterdam, Netherlands on Jan. 29-Feb. 2, 1995, pp. 408-412.
Benard et al., “A Titanium—Nickel Shape-Memory Alloy Actuated Micropump,” Proceedings of Transducers '97, 1997 International Conference on Solid-State Sensors and Actuators, held in Chicago, Il., Jun. 16-19, 1997, 1:361-364 (1997).
Brechtel et al.; “Control of the electroosmotic flow by metal-salt-containing buffers”, J Chromatography A, 1995, pp. 97-105, vol. 716.
Bryzek et al.; “Micromachines on the March”, IEEE Spectrum, 1994, pp. 20-31, vol. 31, No. 5.
Buchaillot et al.; “Silicon nitride thin films Young's modulus determination by an optical non-destructive method”, Jpn. J Appl Phys, 1995, pp. L794-L797, vol. 36, No. 2:6B.
Chiu et al.; “Patterned Deposition of Cells and Proteins onto Surfaces by Using Three-Dimensional Microfluidic Systems”, Proc. Natl. Acad. Sci., 2000, pp. 2408-2413, vol. 97, No. 6.
Chou et al. “A microfabricated device for sizing and sorting DNA molecules”, Applied Physical Sciences, Biophysics, Proc. Natl. Acad. Sci., 1999, pp. 11-13, vol. 96, U.S.A.
Delamarche et al.; “Patterned delivery of immunoglobulins to surfaces using microfluidic networks”, Science, 1997, pp. 779-781, vol. 276.
Duffy et al. “Patterning Electroluminescence Materials with Feature Sizes as Small as 5 μm Using Elastomeric Membranes as Masks for Dry Lift-Off”, Advanced Materials, 1999, pp. 546-552, vol. 11, No. 7.
Duffy et al. “Rapid Prototyping of Microfluidic Switches in Poly(dimethylsiloxane) and Their Actuation by Electro-Osmotic Flow” Journal of Microeng, 1999, pp. 211-217, vol. 9.
Duffy et al. “Rapid Prototyping of Microfluidic Systems in Poly(dimethylsiloxane)”, Analytical Chemistry, 1998, pp. 4974-4984, vol. 70, No. 23.
Effenhauser et al.; “Integrated capillary electrophoresis on flexible silicone microdevices: Analysis of DNA restriction fragments and detection of single DNA molecules on microchips”, Anal. Chem, 1997, pp. 3451-3457, vol. 69.
Effenhauser et al.; “Integrated chip-based capillary electrophoresis”, Electrophoresis, 1997, pp. 2203-2213, vol. 18.
Fahrenberg et al. “A microwave system fabricated by thermoplastic molding”, J Micromech Microeng, 1995, pp. 169-171, vol. 5.
Fu et al.; “A microfabricated fluorescence-activated cell-sorter”, Nature Biotechnology, 1999, pp. 1109-1111, vol. 17.
Gass et al., “Integrated flow-regulated silicon micropump,” Sensors and Actuators A Physical, 1994, p. 335-338, vol. 43.
Gerlach, T., “Pumping Gases by a Silicon Micro Pump with Dynamic Passive Valves,” Proceedings of Transducers '97, 1997 International Conference on Solid-State Sensors and Actuators, held in Chicago, Il., Jun. 16-19, 1997, pp. 357-360, vol. 1.
Goll et al., “Microvalves with bistable buckled polymer diaphragms,” J. Micromech. Microeng., 1996, pp. 77-79, vol. 6.
Gravesen et al.; “Microfluids—A Review”, Journal Micromech Microeng, 1993, pp. 168-192, vol. 3.
Harrison et al., “Micromachining a Miniaturized Capillary Electrophoresis-Based Chemical Analysis System on a Chip,” Science, 1993, pp. 895-897, vol. 261.
Hornbeck et al., “Bistable Deformable Mirror Device,” Spatial Light Modulators and Applications 1988 Technical Digest Series, vol. 8, Postconference Edition, Summaries of papers presented at the Spat

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