Catalyst – solid sorbent – or support therefor: product or process – Catalyst or precursor therefor – Plural component system comprising a - group i to iv metal...
Patent
1997-07-22
2000-02-29
Adams, Donald E.
Catalyst, solid sorbent, or support therefor: product or process
Catalyst or precursor therefor
Plural component system comprising a - group i to iv metal...
502 1, 502 2, 502102, 502103, 502150, 50252714, 50252716, 50252717, 50252724, 435 4, 436518, 556 1, B01J 3100, B01J 3700, C08F 402
Patent
active
060309172
ABSTRACT:
The present invention relates, inter alia, to methodologies for the synthesis, screening and characterization of organometallic compounds and catalysts (e.g., homogeneous catalysts). The methods of the present invention provide for the combinatorial synthesis, screening and characterization of libraries of supported and unsupported organometallic compounds and catalysts (e.g., homogeneous catalysts). The methods of the present invention can be applied to the preparation and screening of large numbers of organometallic compounds which can be used not only as catalysts (e.g., homogeneous catalysts), but also as additives and therapeutic agents.
REFERENCES:
patent: 4752597 (1988-06-01), Turner
patent: 5064802 (1991-11-01), Stevens et al.
patent: 5198401 (1993-03-01), Turner et al.
patent: 5278119 (1994-01-01), Turner et al.
patent: 5318935 (1994-06-01), Canich et al.
patent: 5447895 (1995-09-01), Marks et al.
patent: 5470927 (1995-11-01), Turner et al.
patent: 5470993 (1995-11-01), Devore et al.
patent: 5474796 (1995-12-01), Brennan
patent: 5495036 (1996-02-01), Wilson et al.
patent: 5502017 (1996-03-01), Marks et al.
patent: 5504049 (1996-04-01), Crowther et al.
patent: 5550094 (1996-08-01), Ali et al.
patent: 5599761 (1997-02-01), Turner
patent: 5646084 (1997-07-01), Patton et al.
patent: 5679548 (1997-10-01), Barbas et al.
Burger et al Synthetic ionophores. Encoded combinatorial libraries of cyclen-based receptors for Cu 2 + and Co2 +. J. Org. Chem. 60: 7382-7383, 1995.
Lenzoff, C. The use of insoluble polymer supports in general organic synthesis. Acc. Chem. Res. 11: 327-333, 1978.
Gallop et al Applications of combinatoral technologies to drug discovery 1. J. Med. Chem. 37(9): 1233-1251, Apr. 1994.
Gordon et al Applications of combinatoral technologies to drug discovery 2. J. Med. Chem. 37(10): 1385-1401, May 1995.
Thompson, Lorin A., et al., "Straightforward and general method for coupling alcohols to solid supports," Tetrahedron Letters, vol. 35, No. 50, pp. 9333-9336, 1994.
Menger, F.M., et al., "Phosphatase catalysis developed via combinatorial organic chemistry," J. Org. Chem., vol. 60, pp. 6666-6667, 1995.
Roach, Peter L., et al., "Crystal structure of isopenicillin N synthase is the first from a new structural family of enzymes," Nature, vol. 375, pp. 700-704, 1995.
Cole, Bridget M., et al., "Discovery of chiral catalysts through ligand diversity: Ti-catalyzed enantioselective addition of TMSCN to meso epoxides," Angew. Chem. Ed. Engl., vol. 35, pp. 1668-1671, 1996.
Shibata, Noro, et al., "Resin-bound peptide libraries showing specific metal ion binding," Bioorg. Med. Chem. Lett., vol. 7, pp. 413-416, 1997.
Gilbertson, Scott R., et al., "Versatile Building Block for the Synthesis of Phosphine-Containing Peptides: The Sulfide of Diphenylphosphinoserine," J. Am. Chem. Soc., vol. 116, pp. 4481-4482, (1994).
Menger, R.M., et al., "Phosphatase Catalysis Developed via Combinatorial Organic Chemistry," J. Org. Chem., vol. 60, pp. 6666-6667, (1995).
Liu, Guangcheng, et al., "A General Solid-Phase Synthesis Strategy for the Preparation of 2-Pyrrolidinemethanol Ligands," J. Org. Chem., vol. 60, pp. 7712-7713, (1995).
Malin, Reinhard, et al., "Identification of Technetium-99m Binding Peptides Using Combinatorial Cellulose-Bound Peptide Libraries," J. Am. Chem. Soc., vol. 117, pp. 11821-11822, (1995).
Xiang, X.-D., et al., "A Combinatorial Approach to Materials Discovery," Science, vol. 268, pp. 1738-1740, (1995).
Molecular Diversity and Combinatorial Chemistry, Chaiken, Irwin M and Janda Kim D. (Eds.), American Chemical Society, Washington, DC, USA, Chapter 12, pp. 128-136, (1996).
Gilbertson, Scott R., et al., "Synthesis of Phosphine-Rhodium Complexes Attached to a Standard peptide Synthesis Resin," Organometallics, vol. 15, pp. 4678-4680, (1996).
Burgess, Kevin, et al., "New Catalysts and Conditions for a C-H Insertion Reaction Identified by High Throughput Catalyst Screening," Angew. Chem. Int. Ed. Engl.,vol. 35, No. 2, pp. 220-222, (1996).
Cole, Bridget M., et al., "Discovery of Chiral Catalysts through Ligand Diversity: Ti-Catalyzed Enantioselective Addition TMSCN to meso Epoxides,"Angew, Chem. Int. Ed. Engl., vol. 35, No. 15, pp. 1668-1671, (1996).
Gilbertson, Scott R., et al., "The Combinatorial Synthesis of Chiral Phosphine Ligands," Tetrahedron Letters, vol. 37, No. 36, pp. 6475-6478, (1996).
Menger, Fredric M., et al., "A Combinatorially Developed Reducing Agent," Chem. Commun., pp. 633-634, (1996).
Gennari, Cesare, et al., "Combinatorial Libraries: Studies in Molecular Recognition and the Quest for New Catalysts," Liebigs Ann./Recueil, pp. 637-647, (1997).
Shimizu, Ken D., et al., "Search for Chiral Catalysts Through Ligand Diversity: Substrate-Specific Catalysts and Ligand Screening on Solid Phase," Angew. Chem. Int. Ed. Engl., vol. 36, No. 16, pp. 1704-1707, (1997).
Burger, et al., J. Org. Chem., 60:7382-7383 (1995).
Francis, et al., J. Am. Chem. Soc., 118:8983-8984 (1996).
Moates, et al., Ind. Eng. Chem. Res., 35:4801-4803 (1996).
Guerin et al., "Conformationally Rigid Diamide Complexes: Synthesis and Structure of Tantalum (III) Alkyne Derivatives," Organometallics, 1995, 14, 3154-3156.
Johnson et al., "New Pd(II)- and Ni(II)-Based Catalysts for Polymerization of Ethylene and .alpha.-Olefins," J. Am. Chem. Soc., 1995, 117, 6414-6415.
Scollard et al., "Living Polymerization .alpha.-Olefins by Chelating Diamide Complexes of Titanium," J. Am. Chem. Soc., 1996, 118, 10008-10009.
Boussie Thomas
Goldwasser Isy
McFarland Eric
Murphy Vince
Powers Timothy
Adams Donald E.
Ricigliano Joseph W.
Symyx Technologies Inc.
LandOfFree
Combinatorial synthesis and analysis of organometallic compounds does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Combinatorial synthesis and analysis of organometallic compounds, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Combinatorial synthesis and analysis of organometallic compounds will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-682796