Combinatorial strategies for polymer synthesis

Chemistry: analytical and immunological testing – Including sample preparation – Volumetric liquid transfer

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436 89, 436 94, 73863, 73864, 7386481, 141 31, 422100, B01L 302

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active

060401931

ABSTRACT:
An array is created by moving a dispenser toward a solid support until a tip of the dispenser touches the support, withdrawing the tip from the surface and releasing a drop of 5 nanoliters or less in an area smaller than 1 mm.sup.2 to create an array of at least 100 spots.

REFERENCES:
patent: 3615240 (1971-10-01), Sanz
patent: 3848998 (1974-11-01), Yonekura et al.
patent: 4166457 (1979-09-01), Jacobsen et al.
patent: 4282287 (1981-08-01), Giese
patent: 4327073 (1982-04-01), Huang
patent: 4378333 (1983-03-01), Laipply
patent: 4392362 (1983-07-01), Little
patent: 4483920 (1984-11-01), Gillespie et al.
patent: 4542102 (1985-09-01), Dattagupta et al.
patent: 4562157 (1985-12-01), Lowe et al.
patent: 4584277 (1986-04-01), Ullman et al.
patent: 4586546 (1986-05-01), Mezei et al.
patent: 4591570 (1986-05-01), Chang
patent: 4598049 (1986-07-01), Zelinka et al.
patent: 4613566 (1986-09-01), Potter
patent: 4668476 (1987-05-01), Bridgham et al.
patent: 4675301 (1987-06-01), Charneski et al.
patent: 4677054 (1987-06-01), White et al.
patent: 4681870 (1987-07-01), Balint, Jr. et al.
patent: 4689405 (1987-08-01), Frank
patent: 4704256 (1987-11-01), Hood et al.
patent: 4704353 (1987-11-01), Humphries et al.
patent: 4711955 (1987-12-01), Ward et al.
patent: 4728502 (1988-03-01), Hamill
patent: 4728591 (1988-03-01), Clark et al.
patent: 4737344 (1988-04-01), Koizumi et al.
patent: 4746490 (1988-05-01), Saneii
patent: 4755458 (1988-07-01), Rabbani et al.
patent: 4762881 (1988-08-01), Kauer
patent: 4818492 (1989-04-01), Shimizu
patent: 4820630 (1989-04-01), Taub
patent: 4833092 (1989-05-01), Geysen
patent: 4849513 (1989-07-01), Smith et al.
patent: 4855225 (1989-08-01), Fung et al.
patent: 4861420 (1989-08-01), Knutti et al.
patent: 4861866 (1989-08-01), Durrum et al.
patent: 4868103 (1989-09-01), Stavrianopoulos et al.
patent: 4874500 (1989-10-01), Madou et al.
patent: 4877745 (1989-10-01), Hayes et al.
patent: 4923901 (1990-05-01), Koester et al.
patent: 4925785 (1990-05-01), Wang et al.
patent: 4937188 (1990-06-01), Giese et al.
patent: 4943032 (1990-07-01), Zdeblick
patent: 4966646 (1990-10-01), Zdeblick
patent: 4981783 (1991-01-01), Augenlicht et al.
patent: 4987065 (1991-01-01), Stavrianopoulos et al.
patent: 4988617 (1991-01-01), Landegren et al.
patent: 4994373 (1991-02-01), Stavrianopoulos et al.
patent: 4997521 (1991-03-01), Howe et al.
patent: 5002867 (1991-03-01), Macevicz
patent: 5011770 (1991-04-01), Kung et al.
patent: 5026773 (1991-06-01), Steel
patent: 5026840 (1991-06-01), Dattagupta et al.
patent: 5028525 (1991-07-01), Gray et al.
patent: 5037882 (1991-08-01), Steel
patent: 5043265 (1991-08-01), Tanke et al.
patent: 5053454 (1991-10-01), Judd
patent: 5077085 (1991-12-01), Schnur et al.
patent: 5077210 (1991-12-01), Eigler et al.
patent: 5079600 (1992-01-01), Schnurr et al.
patent: 5082830 (1992-01-01), Brakel et al.
patent: 5094594 (1992-03-01), Brennan
patent: 5100626 (1992-03-01), Levin
patent: 5143849 (1992-09-01), Barry et al.
patent: 5143854 (1992-09-01), Pirrung et al.
patent: 5175209 (1992-12-01), Beattie et al.
patent: 5200051 (1993-04-01), Cozzette
patent: 5202231 (1993-04-01), Drmanac et al.
patent: 5215882 (1993-06-01), Bahl et al.
patent: 5232829 (1993-08-01), Longiaru et al.
patent: 5279558 (1994-01-01), Kriesel
patent: 5288514 (1994-02-01), Ellman
patent: 5310893 (1994-05-01), Erlich et al.
patent: 5324633 (1994-06-01), Fodor et al.
patent: 5338688 (1994-08-01), Deeg et al.
patent: 5348855 (1994-09-01), Dattagupta et al.
patent: 5384262 (1995-01-01), Piasio et al.
patent: 5405783 (1995-04-01), Pirrung et al.
patent: 5412087 (1995-05-01), McGall et al.
patent: 5436327 (1995-07-01), Southern et al.
patent: 5445934 (1995-08-01), Fodor et al.
patent: 5447841 (1995-09-01), Gray et al.
patent: 5455008 (1995-10-01), Earley et al.
patent: 5465629 (1995-11-01), Waylett, Jr.
patent: 5486452 (1996-01-01), Gordon et al.
patent: 5489507 (1996-02-01), Chehab
patent: 5492806 (1996-02-01), Drmanac et al.
patent: 5510270 (1996-04-01), Fodor et al.
patent: 5525464 (1996-06-01), Drmanac et al.
patent: 5545531 (1996-08-01), Rava et al.
patent: 5593839 (1997-01-01), Hubbell et al.
patent: 5631734 (1997-05-01), Stern et al.
patent: 5653939 (1997-08-01), Hollis et al.
patent: 5667972 (1997-09-01), Drmanac et al.
patent: 5677195 (1997-10-01), Winkler et al.
patent: 5695940 (1997-12-01), Drmanac et al.
patent: 5700637 (1997-12-01), Southern
patent: 5770151 (1998-06-01), Roach et al.
patent: 5807522 (1998-09-01), Brown et al.
Urdea et al., "A Novel Method For The Rapid Detection of Specific Nucleotide Sequences in Crude Biological Samples Without Blotting or Radioactivity; Application to the Analysis of Hepatitis B Virus in Human Serum," Gene 61,253-264 (1987).
Frank, et al., "Simultaneous Synthesis and Biological Applications of DNA Fragments: An Efficient and Complete Methodology," Methods in Enzymology, 154:221-251 (1987).
Augenlicht, et al., "Cloning and Screening of Sequences Expressed in a Mouse Colon Tumor," Cancer Research, 42,1088-1093.
Masiakowski, et al., "Cloning of cDNA sequences of hormone-regulated genes from the MCF-7 human breast cancer cell line," Nucleic Acids Research, 10:7895-7903 (1982).
Bartsh et al., "Cloning of mRNA sequences from the human colon: Preliminary characterization of defined mRNAs in normal neoplastic tissues," Br. J. Cancer, 54:791-798 (1986).
Haase et al "Detection of two Viral Genomes in Single Cells by Double-Label Hybridization in Situ and Color Microradioautography," Science 227, 189-192 (1985).
Lanier, et al, "Human Lymphocyte Subpopulations Identified by using Three-Color Immunofluorescence and Flow Cytometry Analysis", The Journal of Immunology, 132:151-156 (1984).
Wallace et al., "Hybridization of synthetic oligodeoxyribonucleotides to *x 174 DNA: the effect of single base pair mismatch", Nucleic Acids Research, 11:3543-3557 (1979).
Laskey, et al., "Messenger RNA prevalence in sea urchin embryos measured with cloned cDNAs," Proc. Nat. Acad. Sci. USA, 77:5317-5321 (1986).
Hanahan et al., "Plasmid screening at high colony density", Gene 10:63-67 (1980).
Hanahan et al., "Plasmid screening at high density," Methods in Enzymology, 100:333-342 (1983).
Love, et al., "Screening of Lambda Library for Differentially Expressed Genes Using in Vitro Transcripts," Anal Biochem, 150:429-41 (1985).
Wu, et al., "Synthesis and Properties of Adnosine-5'-triphosphoro-y-1-(5-sulfonic acid) naphthyl Ethylamidate: A Fluorescent Nucleotide Substrate for DNA-Dependent RNA Polymerase from Escherichia coli" Arch Biochem Biophys, 246:564-71 (1989).
Yarbrough, et al., "Synthesis and Properties of Flourescent Nucleotide Substrates for DNA-dependent RNA Polymerases," J. Biol. Chem. 254:12069-73 (1979).
Titus, et al., "Texas Red, A Hydrophilic, Red-Emitting Fluorophore for use with Fluorescein in Dual Parameter Flow Microfluorometric and Fluorescence Microscopic Studies," Journal of Immunological Methods, 50:193-204. (1982).
Loken, et al, "Three-Color Immunofluorescence Analysis of Leu Antigens on Human Peripheral Blood Using Two Lasers on a Fluorescence-Activated Cell Sorter," Cymoetry 5:151-158 (1984).
Sim, et al., "Use of a cDNA Library for Studies on Evolution and Developmental Expression of the Chorion Multigene Families", Cell 18:1303-1316 (1979).
Augenlicht et al., "Expression of Cloned Sequences in Biopsies of Human Colonic Tissue and in Colonic Carcinoma Cells Induced to Differentiate in Vitro," Cancer Research, 47, 6017-6021 (1987).
Urdea et al., "A Comparison of non-radioisotopic hybridization assay methods using fluorescent, chemiluminescent and enzyme labeled synthetic oligodeoxyribonucleotide probes," Nucleic Acids Research, 16: 4937-4956 (1988).
Lysov et al., "A New Method For Determining the DNA Nucleotide Sequence by Hybridization with Oligonucleotides," Doklady Biochemistry, 303:436-438 (1989).
Khrapko et al., "An Oligonucleotide Hybridization Approach to DNA Sequencing," FEBS Letters, 256:118-122 (1989).
Hopman et al. "Bi-color detection of two target DNAs by non-radioactive in situ hybridization," Histochemistry, 85:1-4 (1986).
Widacki et al., "Biochemi

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