Combinatorial production of nucleotide and nucleoside (XiTP)...

Details Combinatorial production of nucleotide and nucleoside (XiTP)... Combinatorial production of nucleotide and nucleoside (XiTP)...

2008-01-15

2008-01-15

Anderson, Rebecca (Department: 1626)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C548S517000

Reexamination Certificate

active

07319148

ABSTRACT:
The invention concerns novel nucleotide analogues comprising a reactive hydrazide function used as initial synthons for preparing compounds (formula I) capable of inducing mutations or capable of inhibiting a DNA polymerase or a kinase. The invention also concerns nucleic acids comprising said nucleotide and nucleoside analogues. Among such compounds, can be cited in particular the compound of formula (I)

REFERENCES:
Hoops et al., Template directed incorporation of nucleotide mixtures using azoe-nucleobase analogs, Nucleic Acids Research, 1997, vol. 25, No. 24, pp. 4866-4871.
Sarafianos et al., Designing anti-AIDS drugs targeting the major mechanism of HIV-1 RT resistance to nucleoside analog drugs, The International Journal of Biochemistry & Cell Biology 36 (2004) 1706-1715.
Sanger et al., PNAS USA, vol. 74, No. 12, pp. 5463-5467, Dec. 1977.
Sonveaux, E., “Protecting Groups In Oligonucleotide Synthesis,” Methods in Molecular Biology, vol. 26, Protocols for Oligonucleotide Conjugates, Ed. Agrawal S., 1994, Hamana Press Inc.
J.T. Witkowski, “Design, Synthesis, and Broad Spectrum Antiviral Activity of 1-β-D-Ribofuranosyl-1,2,4-triazole-3-carboxamide and Related Nucleosides1,2”Journal of Medicinal Chemistry, vol. 15, No. 11, pp. 1150-1154, (1972).
M. Teresa Garcia-López, et al., “Studies of New Routes for the Synthesis of 4- and 5-Aminoimidazole Nucleoside Derivatives”,J. Heterocyclic Chem., vol. 19, pp. 233-235, (1982).
T.P. Nedorezova, et al., “Effects of 4,5-disubstituted 1,2,3-triazoles and their N2-ribosides on pyrimidine precursors incorporation into nucleic acids of tumor cells”,Chemical Abstracts, vol. 106:95702z, No. 13, (1987).
I.D. Shingarova, et al., “Nucleosides of 4-(methylthio)-1,2,3-triazole-5-carboxylic Acid Derivatives”,Chemical Abstracts, vol. 108:6331d, No. 1, (1988).
I.D. Shingarova, et al., “Position of glycosidation of 5-substituted 4-chloro-1,2,3-triazoles”,Chemical Abstracts, vol. 108:187169a, No. 21, (1988).
C. Le Bec, et al., “Derivatives of Imidazole-4-carboxamide as Substrates for Vairous DNA Polymerases”,Nucleosides&Nucleotides, vol. 16, pp. 1301-1302, (1997).
Sylvie Pochet, et al., “Imidazole-4-Carboxamide and 1,2,4-Triazole-3-Carboxamide Deoxynucleotides as Simpliefied DNA Building Blocks with Ambiguous Pairing Capacity”,Nucleosides&Nucleotides, vol. 17, pp. 2003-2009, (1998).
M. Sala, et al., “Ambiguous base pairing of the purine analogue 1-(2)-deoxy-β-D-ribofuranosyl)-imidazole-4-carboxamide during PCR”,Nucleic Acids Research, vol. 24, pp. 3302-3306, (1996).

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