Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2008-07-08
2008-07-08
Epperson, Jon D (Department: 1639)
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
C534S790000, C546S201000, C514S254090
Reexamination Certificate
active
10957159
ABSTRACT:
Combinatorial libraries that contains various different 4, 5 fused 3-substituted-2-pyrrolocarboxylic acids for screening pharmacological activity and methods of synthesizing said libraries.
REFERENCES:
patent: 4263304 (1981-04-01), Ishizumi et al.
patent: 5463564 (1995-10-01), Agrafiotis et al.
patent: 5684032 (1997-11-01), Elliott et al.
patent: WO 86/00991 (1986-02-01), None
Cawse, J. N. “Experimental Strategies for Combinatorial and High Throughput Materials Development” GE Research & Development Center Technical Information Series Sep. 2000, 1-15.
Silverman, Richard B. The Organic Chemistry of Drug Design and Drug Action. New York: Academic Press, Inc. 1992, pp. 19-23, especially Table 2.2.
Tois et al. “Vilsmeier Formylation of 2-Carboxyindoles and Preparation of O-Benzylhydroxyureas on Solid Phase” J. Comb. Chem. 2001, 3, 542-545.
(Lee at al. “Solid-Phase Rhodium Carbenoid N-H Insertion Reactions: the Synthesis of a Diverse Array of Indoles” J. Comb. Chem. 2003, 5(2), 188-196.
Lee, Sang-Hyeup, et al.,Solid-Phase Rhodium Carbenoid N-H Insertion Reactions: the Synthesis of a Diverse Array of Indoles,Journal of Combinatorial Chemisrty, 5(2), pp. 188-196, (2003), XP002323268.
Lee, Sang-Hyeup, et al.,Solid Phase Rhodium Carbenoid N-H Insertion Reactions: the Synthesis of a Diverse Array of Indoles,Journal of Combinatorial Chemistry, 5(2), Supplementary Information, pp. S1-S16 (2003), XP002323269.
Tois, J., et al.,Solid-Phase Bromination and Suzuki Coupling of 2-Carboxyindoles,Combinatorial Chemistry and High Throughput Screening, 4(6), pp. 521-524, (2001), XP009045852.
Yamazaki, et al.,Solid-Phase Synthesis of Indolecarboxylates using Palladium-Catalyzed Reactions,J. Org. Chem, vol. 68, No. 15, pp. 6011-6019 (2003), XP002323296.
Bashiardes, G., et al.,A new method for the Synthesis of Plurisubstituted Pyrroles,Tetrahedron Letters, Elsevier Science Publishers, Amsterdam NL, vol. 44, No. 46, pp. 8417-8420 (2003), XP004463878.
Bunker, A.M., et al.,1,3-Diaryl-2-Carboxyindoles as Potent Non-Peptide Endothelin Antagonists,Bioorganic & Medicinal Chemistry Letters, Oxford, GB; vol. 6, No. 9, pp. 1061-1066 (1996), XP004134909.
Mederski, W.W.K.R., et al.,N-Aryl Heterocycles Via Coupling Reactions with Arylboronic Acids,Tetrahedron, Elsevier Science Publishers, Amsterdam, NL, vol. 55, No. 44, pp. 12757-12770 (1999), XP004180368.
Abreu, A.S., et al.,Synthesis and Intramolecular Cyclization of Novel Beta, Beta-Bis-(benzo 'b!thienyl)dehydroalanine Derivatives,Tetrahedron Letters, Elsevier Science Publishers, Amsterdam, NL, vol. 44, No. 16, pp. 3377-3379 (2003), XP004417077.
Malapel-Andrieu, B., et al.,Synthesis and Reactivity of Substituted 3- '(Trifluoromethly)sulfony!oxy)-1H-Indole-2-Carboxylate in Palladium-Catalyzed Reactions,Tetrahedron Elsevier Science Publishers, Amsterdam, NL, vol. 54, No. 37, pp. 11079-11094 (1998), XP004132304.
Liao Y-X, et al.,Efficient Synthesis of Trisubstituted '1!benzopyrando '4,3-b!pyrrol-4(1 H)-One derivatives from 4-Hydroxycoumarin,Tetrahedron Letters, Elsevier Sciense Publishers, Amsterdam, NL, vol. 44, No. 8, pp. 1599-1602 (2003), XP0044205280.
Database Beilstein Beilstein Institut Zur Forderung Der Chemischen Wissenschaften, Frankfurt AM Main, DE; XP002323272, Database Accession No. 298982, 246940, 289846, 272328 Abstract & Huges, et al: J. Proc. R. Soc. N.S.W., vol. 71, pp. 475-482 (1937-1938).
Database Beilstein Beilstein Institut Zur Forderung Der Chemischen Wissenschaften, Frankfurt AM Main, DE; XP002323273, Database Accession No. 9213207, Abstract & Nakamur, et al., Org. Lett., vol. 4, No. 14, pp. 2317-2320 (2002).
Database Beilstein Beilstein Institut Zur Forderung Der Chemischen Wissenschaften, Frankfurt AM Main, DE; XP002323274, Database Accession No. 7965831, Abstract & Fabio, et al.: Synth. Commun., vol. 28, No. 1, pp. 51-60 (1998).
Database Beilstein Beilstein Institut Zur Forderung Der Chemischen Wissenschaften, Frankfurt AM Main, DE; XP002323275, Database Accession No. 7799589, Abstract & Moloney, et al.: J. Med. Chem., vol. 40, No. 15, pp. 2347-2363 (1997).
Database Beilstein Beilstein Institut Zur Forderung Der Chemischen Wissenschaften, Frankfurt AM Main, DE; XP002323276, Database Accession No. 7542064, Abstract & Fuerstner, et al.: Tetrahedron, vol. 52, No. 21, pp. 7329-7344 (1996).
Database Beilstein Beilstein Institut Zur Forderung Der Chemischen Wissenschaften, Frankfurt AM Main, DE; XP002323277, Database Accession No. 7383229, Abstract & Choshi, et al.: J. Org. Chem., vol. 60, No. 18, pp. 5899-5904 (1995).
Database Beilstein Beilstein Institut Zur Forderung Der Chemischen Wissenschaften, Frankfurt AM Main, DE; XP002323278, Database Accession No. 344331, Abstract & Cook, et al.: J. Chem. Soc, pp. 397-400 (1943).
Database Beilstein Beilstein Institut Zur Forderung Der Chemischen Wissenschaften, Frankfurt AM Main, DE;XP002323279, Database Accession No. 5627914, Abstract & Ishii, et al.: Chem.Pharm.Bull., vol. 31, No. 12 , pp. 4391-4400 (1983).
Database Beilstein Beilstein Institut Zur Forderung Der Chemischen Wissenschaften, Frankfurt AM Main, DE; XP002323280, Database Accession No. 247605, Abstract & Sempronj: Gazz. Chim Ital., vol. 68, pp. 263-268 (1938).
Database Beilstein Beilstein Institut Zur Forderung Der Chemischen Wissenschaften, Frankfurt AM Main, DE; XP002323281, Database Accession No. 1150849, Abstract & Tsuge, et al: Chem. Lett., pp. 1407-1410 (1979).
Database Beilstein Beilstein Institut Zur Forderung Der Chemischen Wissenschaften, Frankfurt AM Main, DE; XP002323282, Database Accession No. 5978943, Abstract & Hirai, et al., J. Med. Chem., vol. 23, No. 7, pp. 764-773 (1980).
Database Beilstein Beilstein Institut Zur Forderung Der Chemischen Wissenschaften, Frankfurt AM Main, DE; XP002323283, Database Accession No. 270866, Abstract & Gabriel, et al., Chem. Ber., vol. 56, p. 1024 (1923).
Database Beilstein Beilstein Institut Zur Forderung Der Chemischen Wissenschaften, Frankfurt AM Main, DE; XP002323284, Database Accession No. 4484374, Abstract & Hiremath, et al., Indian J. Chem. Sect. B, vol. 27, No. 1-12, pp. 756-757 (1988).
Cai Jianping
Goodnow, Jr. Robert Alan
Epperson Jon D
Hoffmann-La Roche Inc.
Johnston George W.
Rocha-Tramaloni Patricia S.
Wildman David E.
LandOfFree
Combinatorial library of 3-aryl-1H-indole-2-carboxylic acid does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Combinatorial library of 3-aryl-1H-indole-2-carboxylic acid, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Combinatorial library of 3-aryl-1H-indole-2-carboxylic acid will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3923259